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The Gene Regulation Ontology (GRO) is designed as a novel approach to model complex events that are part of the gene regulatory processes. We introduce the design requirements for such a conceptual model and discuss terminological resources suitable to base its construction on. The ontology defines gene regulation events in terms of ontological classes and(More)
MOTIVATION Gene Ontology (GO) has been manually developed to provide a controlled vocabulary for gene product attributes. It continues to evolve with new concepts that are compiled mostly from existing concepts in a compositional way. If we consider the relatively slow growth rate of GO in the face of the fast accumulation of the biological data, it is much(More)
The need for extracting general biological interactions of arbitrary types from the rapidly growing volume of the biomedical literature is drawing increased attention, while the need for this much diversity also requires both a robust treatment of complex linguistic phenomena and a method to consistently characterize the results. We present a biomedical(More)
As the importance of automatically extracting and analyzing various natural language assertions about protein-protein interactions in biomedical publications is recognized, many uses of natural language processing techniques are proposed in the literature. However, most proposals to date make rather simplifying assumptions about the syntactic aspects of(More)
Taxonomies are the backbone of many structured, semantic knowledge resources. Recent works for extracting taxonomic relations from text focused on collecting lexical-syntactic patterns to extract the taxonomic relations by matching the patterns to text. These approaches, however, often show low coverage due to the lack of contextual analysis across(More)
UNLABELLED Search engines running on MEDLINE abstracts have been widely used by biologists to find publications that are related to their research. The existing search engines such as PubMed, however, have limitations when applied for the task of seeking textual evidence of relations between given concepts. The limitations are mainly due to the problem that(More)
Biomedical researchers have to efficiently explore the scientific literature, keeping the focus on their research. This goal can only be achieved if the available means for accessing the literature meet the researchers' retrieval needs and if they understand how the tools filter the perpetually increasing number of documents. We have examined existing(More)