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BACKGROUND The activating BRAF(V600E) mutation is the most common genetic alteration reported in papillary thyroid carcinoma (PTC). While some reports suggest the BRAF(V600E) mutation is associated with factors predicting a poor prognosis and recurrence, this remains a controversial issue. AIM To determine whether the presence of the BRAF(V600E) mutation(More)
Haptics is a valuable tool in minimally invasive surgical simulation and training. We discuss important aspects of haptics in MISST, such as haptic rendering and haptic recording and playback. Minimally invasive surgery has revolutionized many surgical procedures over the last few decades. MIS is performed using a small video camera, a video display, and a(More)
This paper presents a motion artifact reduction algorithm for a real-time, wireless and wearable photoplethysmography (PPG) device for measuring heart beats. A wearable finger band PPG device consists of a 3-axis accelerometer, infrared LED, photo diode, a microprocessor and wireless module. Sources of the motion artifacts were investigated from the hand(More)
Soft tissue characterization and modeling based on living tissues has been investigated in order to provide a more realistic behavior in a virtual reality based surgical simulation. In this paper, we characterize the nonlinear viscoelastic properties of intra-abdominal organs using the data from in vivo animal experiments and inverse FE parameter estimation(More)
Palpation is an intuitive examination procedure in which the kinesthetic and tactile sensations of the physician are used. Although it has been widely used to detect and localize diseased tissues in many clinical fields, the procedure is subjective and dependent on the experience of the individual physician. Palpation results and biomechanics-based(More)
MicroRNAs (miRNAs) are an abundant class of small regulatory RNAs that regulate the stability and translation of cognate mRNAs. Although an increasing number of porcine miRNAs has recently been identified, the full repertoire of miRNAs in pig remains to be elucidated. To identify porcine miRNAs potentially involved in myogenesis and adipogenesis, we(More)
BACKGROUND AND PURPOSE Activation of hepatic stellate cells (HSCs) is a crucial step in the pathogenesis of hepatic fibrosis. Histone deacetylase (HDAC) is an attractive target in liver fibrosis because it plays a key role in gene expression and cell differentiation. We have developed a HDAC inhibitor, N-hydroxy-7-(2-naphthylthio)heptanomide (HNHA), and(More)
Small cell lung cancer (SCLC) is one of the most fatal cancers in humans and many factors are known to be related to its poor prognosis. Immunohistochemical (IHC) stainings were done on SCLC specimens in order to investigate the prognostic value of the apoptosis-related gene expression and the tumor proliferative maker, and the relationships among these IHC(More)
OBJECTIVES The aim of the study was to evaluate the usefulness of the antithyroglobulin autoantibody (TgAb) value at 6-12 months after remnant ablation in predicting recurrence in differentiated thyroid carcinoma patients who had undetectable thyroglobulin (Tg) values. The change in TgAb concentration measured between the time of remnant ablation (TgAb1)(More)
We developed an alternative computer interface using surface electromyography (sEMG) for individuals with spinal cord injuries (SCI) to access a computer. We designed this interface to make a cursor move on a two-dimensional screen and to click using only three muscles: the extensor carpi radialis (R-ECR) and extensor carpi ulnaris (R-ECU) of the right(More)