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Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels
The results are consistent with the hypothesis that differential gene expression underlies pharmacological and physiological heterogeneity observed in neuronal T-type calcium currents, and they provide a molecular basis for the study of T- type channels in particular neurons. Expand
Cloning and Expression of a Novel Member of the Low Voltage-Activated T-Type Calcium Channel Family
It is suggested that α1I plays important roles in determining the electroresponsiveness of neurons, and hence, may be a novel drug target. Expand
Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
Based on the channel's distinctive voltage dependence, slow deactivation kinetics, and 7.5-pS single-channel conductance, it is concluded that this channel is a low-voltage-activated T-type calcium channel. Expand
Molecular Mechanisms of Subtype-Specific Inhibition of Neuronal T-Type Calcium Channels by Ascorbate
This study represents the first mechanistic demonstration of ion channel modulation by ascorbate, and suggests that ascorBate may function as an endogenous modulator of neuronal excitability. Expand
Comparison of the Ca2 +  currents induced by expression of three cloned α1 subunits, α1G, α1H and α1I, of low‐voltage‐activated T‐type Ca2 +  channels
Comparing reactivation after long‐term inactivation was fastest for currents arising from expression of α1I and slowest in cells expressing α1H calcium channels, which may allow correlation of the α1G, α2 +  and α1i induced currents with their in vivo counterparts. Expand
A Molecular Determinant of Nickel Inhibition in Cav3.2 T-type Calcium Channels*
Findings indicate that His-191 in the S3–S4 loop is a critical residue conferring nickel block to Cav3.3.2 and reveal a novel role for the S4 loop to control ion permeation through T-type Ca2+ channels. Expand
Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2) *
It is concluded that the α2δ-2 gene encodes a functional auxiliary subunit of voltage-gated Ca2+ channels, which needs to be explored as a potential tumor suppressor gene linking Ca2-signaling and lung, breast, and other cancer pathogenesis. Expand
A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons
The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.
Reducing Agents Sensitize C-Type Nociceptors by Relieving High-Affinity Zinc Inhibition of T-Type Calcium Channels
It is demonstrated that reducing agents as well as endogenous metal chelators sensitize C-type dorsal root ganglion nociceptors by chelating Zn2+ ions off specific extracellular histidine residues on Cav3.2 T-channels, thus relieving tonic channel inhibition, enhancing Cav3-2 currents, and lowering the threshold for nocICEptor excitability in vitro and in vivo. Expand
Structural Determinants of the High Affinity Extracellular Zinc Binding Site on Cav3.2 T-type Calcium Channels*
The key findings of the study are that the metal binding site is composed of a Asp-Gly-His motif in IS3–S4 and a second aspartate residue in IS2. Expand