Jung-Chan Chang

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Vaccination with irradiated granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting gene-transduced cancer vaccines induces tumoricidal immune responses. In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo(More)
We recently found that polyclonal antibodies to laminin, a basement membrane-related glycoprotein, inhibited murine lung morphogenesis when added to organ cultures of mouse embryonic lung. Using a series of monoclonal anti-laminin antibodies with previously characterized subunit specificity (termed AL-1, AL-2, AL-3, AL-4, and AL-5), the deposition and(More)
M. Ablikim, M. N. Achasov, X. C. Ai, O. Albayrak, M. Albrecht, D. J. Ambrose, A. Amoroso, F. F. An, Q. An, J. Z. Bai, R. Baldini Ferroli, Y. Ban, D. W. Bennett, J. V. Bennett, M. Bertani, D. Bettoni, J. M. Bian, F. Bianchi, E. Boger, I. Boyko, R. A. Briere, H. Cai, X. Cai, O. Cakir, A. Calcaterra, G. F. Cao, S. A. Cetin, J. F. Chang, G. Chelkov, G. Chen, H.(More)
F. P. An, A. B. Balantekin, H. R. Band, M. Bishai, S. Blyth, D. Cao, G. F. Cao, J. Cao, W. R. Cen, Y. L. Chan, J. F. Chang, L. C. Chang, Y. Chang, H. S. Chen, Q. Y. Chen, S. M. Chen, Y. X. Chen, Y. Chen, J.-H. Cheng, J. Cheng, Y. P. Cheng, Z. K. Cheng, J. J. Cherwinka, M. C. Chu, A. Chukanov, J. P. Cummings, J. de Arcos, Z. Y. Deng, X. F. Ding, Y. Y. Ding,(More)
Triggering of the CD3:TCR complex by optimal concentrations of anti-CD3, anti-TCR beta-chain, and allogeneic stimulator cells induced dramatically higher levels (fivefold for anti-CD3, greater than 10-fold for anti-TCR beta-chain, 84-fold for alloantigen) of IL-2 production in spleen CD4+8- T cells than their thymic counterparts, despite comparable levels(More)
CD72 is a 45-kDa glycoprotein that is predominantly expressed on cells of the B lineage, except for plasma cells. Its expression pattern is representative of many B cell-specific proteins, which are essential for B cell development and activation but are down-regulated after B cells become terminally differentiated plasma cells. We have examined the(More)
Th cell development inside the thymus can be defined on the basis of qualitative and quantitative CD4 and CD8 marker expression and follows the pathway of CD4-8- cells----CD4+8+ cells----CD4+8low cells----CD4+8- cells, which presumably emigrate to seed the periphery and serve as functionally mature Th cells. The various cell subpopulations at defined(More)
F. P. An, A. B. Balantekin, H. R. Band, W. Beriguete, M. Bishai, S. Blyth, I. Butorov, G. F. Cao, J. Cao, Y. L. Chan, J. F. Chang, L. C. Chang, Y. Chang, C. Chasman, H. Chen, Q. Y. Chen, S. M. Chen, X. Chen, X. Chen, Y. X. Chen, Y. Chen, Y. P. Cheng, J. J. Cherwinka, M. C. Chu, J. P. Cummings, J. de Arcos, Z. Y. Deng, Y. Y. Ding, M. V. Diwan, E. Draeger, X.(More)