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Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu).
TLDR
Methylation analyses showed that fucoidan had various sugar linkages, and revealed that thefucoidan might have complicated structure, and showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus. Expand
Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice.
TLDR
The results suggest that mast cell tryptase elicits itch through PAR-2 receptor and that NFM inhibits itch-associated responses mainly through the inhibition of mast celltryptase. Expand
Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme.
TLDR
Besides anti-HSV-1 activity, nostoflan showed potent antiviral activities against HSV-2, human cytomegalovirus, and influenza A virus, but no activity against adenovirus and coxsackie virus was observed. Expand
In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans.
TLDR
The results demonstrated that APS might have beneficial therapeutic effects on influenza A virus infection at least in part by modulation of the immune function of macrophages. Expand
Antiherpetic activities of sulfated polysaccharides from green algae.
TLDR
Results revealed that some sulfated polysaccharides from green algae should be promising candidates of antiviral agents which might act on different stages in the virus replication cycle. Expand
Antiviral sulfated polysaccharide from Navicula directa, a diatom collected from deep-sea water in Toyama Bay.
TLDR
A sulfated polysaccharide named naviculan was isolated from a diatom, Navicula directa, collected in deep sea water from Toyama Bay and showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza A virus with selectivity indices of 270, 510 and 32. Expand
Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice.
TLDR
It is suggested that PAR1, PAR2, and PAR4 are involved in itch and that histamine is a cause of itch related to PAR1 andPAR4, but not PAR2. Expand
Repair of wounded monolayers of cultured bovine aortic endothelial cells is inhibited by calcium spirulan, a novel sulfated polysaccharide isolated from Spirulina platensis.
TLDR
It is concluded that Ca-SP may retard the repair process of damaged vascular endothelium through inhibition of vascular endothelial cell proliferation by induction of a lower ability to respond to stimulation by endogenous basic fibroblast growth factor. Expand
Different dorsal horn neurons responding to histamine and allergic itch stimuli
TLDR
The results suggest that allergic itch signal is mediated by primary afferents expressing protease-activated receptor-2 and the neurons receiving signals of protease -associated itch and allergy-associated itch are different from those of histamine-induced itch. Expand
Characterization of structures and antiviral effects of polysaccharides from Portulaca oleracea L.
TLDR
Results of antiviral tests showed that only RP had anti-HSV-2 activity and its anti-herspes simplex virus type 2 target was elucidated to be the step of virus penetration into host cells. Expand
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