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Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera(More)
OBJECTIVE Nearly all China's rural residents and a shrinking fraction of urban residents use solid fuels (biomass and coal) for household cooking and/or heating. Consequently, global meta-analyses of epidemiologic studies indicate that indoor air pollution from solid fuel use in China is responsible for approximately 420,000 premature deaths annually, more(More)
BACKGROUND microRNAs (miRNAs) are endogenous small non-coding RNAs that regulate gene expression at the post-transcriptional level. While the number of known human and murine miRNAs is continuously increasing, information regarding miRNAs from other species such as amphioxus remains limited. RESULTS We combined Solexa sequencing with computational(More)
independent and unbiased research organization to provide high quality, impartial, and relevant science on the health effects of emissions from motor vehicles, fuels, and other environmental sources. All results are provided to industry and government sponsors, other key decisionmakers, the scientific community, and the public. HEI funds research on all(More)
A new class of RNA regulatory genes known as microRNAs (miRNAs) has been found to introduce a whole new layer of gene regulation in eukaryotes. The intensive studies of the past several years have demonstrated that miRNAs are not only found intracellularly, but are also detectable outside cells, including in various body fluids (e.g. serum, plasma, saliva,(More)
BACKGROUND Some epidemiologic studies have reported compromised cognitive and sensory performance among individuals exposed to low concentrations of hydrogen sulfide (H2S). OBJECTIVES We hypothesized a dose-response increase in symptom severity and reduction in sensory and cognitive performance in response to controlled H2S exposures. METHODS In(More)
This study investigated the effects of tetramethylpyrazine (TMP), an active element of traditional Chinese medicine Ligusticum Chuanxiong, on proliferation and differentiation of neural stem cells (NSCs) from rat brain in hypoxia condition and the activation of mitogen-activated protein kinases (MAPKs) signaling pathway during the processes. The results(More)
In this paper, we develop an immersed boundary lattice Boltzmann approach to simulate deformable capsules in flows. The lattice Boltzmann method is utilized to solve the incompressible flow field over a regular Eulerian grid, while the immersed boundary method is employed to incorporate the fluid–membrane interaction with a Lagrangian representation of the(More)
A new incremental support vector machine (SVM) algorithm is proposed which is based on multiple kernel learning. Through introducing multiple kernel learning into the SVM incre-mental learning, large scale data set learning problem can be solved effectively. Furthermore, different punishments are adopted in allusion to the training subset and the acquired(More)
Some gene expression may be regulated by hypoxia-responsive element (HRE) that is bound by hypoxia-inducible factor-1 (HIF-1) which is up-regulated during cerebral ischemia. To explore ischemia/hypoxia-controlled expression and the neuroprotective effects of brain-derived neurotrophic factor (BDNF) after ischemic brain injury, an adenoviral vector using(More)