Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy
- Chunlin Li, Nengpan Zhang, Yimin Zhu
- Biology, MedicineCancer immunology research
- 7 December 2017
Targeting PD-L1 peptide, TPP-1, was found to block PD-1/PD- L1 interactions, leading to T-cell reactivation, improved responses, and inhibition of tumor growth in a xenograft model.
MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib.
- Bing Zheng, Hua Zhu, Y. Shan
- Biology, ChemistryBiochemical and Biophysical Research…
- 3 April 2015
VEGF-C promotes the development of esophageal cancer via regulating CNTN-1 expression.
- P. Liu, Jundong Zhou, Shuyu Zhang
- 1 July 2011
miR-34a inhibits the migration and invasion of esophageal squamous cell carcinoma by targeting Yin Yang-1.
- J. Nie, Xin Ge, Jianping Cao
- BiologyOncology Report
- 1 July 2015
Results of the present study showed that miR-34a is associated with ESCC migration and provides a potential therapeutic and diagnostic target for ESCC.
Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats
- Shuyu Zhang, Chuanjun Song, Jinchang Wu
- Biology, MedicineRadiation Oncology
- 17 January 2012
Subcutaneous injection of Ad-HO1-EGFP demonstrated significant improvement in radiation-induced skin injury and provided evidences for the protective role of HO-1 in alleviating radiation- induced skin damage in rats, which is helpful for the development of therapy for radiation-related skin injury.
Prostate cancer in the senior men from rural areas in east district of China: contemporary management and 5-year outcomes at multi-institutional collaboration.
- Q. Shao, J. Ouyang, Yuanyuan Zhang
- MedicineCancer Letters
- 28 February 2012
Upregulation of AUF1 is involved in the proliferation of esophageal squamous cell carcinoma through GCH1.
- Yi Gao, Wenjie Wang, Shuyu Zhang
- BiologyInternational Journal of Oncology
- 1 November 2016
The overexpression of AUF1 in esophageal carcinoma is demonstrated and GCH1 is identified asAUF1's effector for the proliferation of ESCC cells.
Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.
- Shuyu Zhang, Jun Hao, C. Shao
- 1 August 2011
The present findings illustrate the mechanism driving miR-132 downregulation and the important role in pancreatic cancer development and identify 12 differentially expressed miRNAs.
RAD18 may function as a predictor of response to preoperative concurrent chemoradiotherapy in patients with locally advanced rectal cancer through caspase‐9‐caspase‐3‐dependent apoptotic pathway
- Xueqi Yan, Jie Chen, Jundong Zhou
- Medicine, BiologyCancer Medicine
- 29 April 2019
RAD18, an E3 ubiquitin‐linked enzyme, played a fundamental role in predicting the response of LARC patients to nCRT and implied that RAD18 could be a new biomarker to predict LARC Patients who might benefit from n CRT and provide new strategies for clinical treatment of L ARC.
Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells*
- Jundong Zhou, Shuyu Zhang, W. Ding
- BiologyJournal of Biological Chemistry
- 29 August 2012
It is demonstrated for the first time that activation of PPARα suppresses hypoxia-induced HIF-1α signaling in cancer cells, providing novel insight into the anticancer properties ofPPARα agonists.