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- Jörg König, Mark Hartel, +5 authors Dietrich Keppler
- International journal of cancer
- 2005
Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the… (More)
- Dale E. Bockman, Junchao Guo, Peter Buechler, Michael Müller, Frank Thomas Bergmann, Helmut Friess
- Laboratory Investigation
- 2003
Notwithstanding the importance of understanding how pancreatic ductal adenocarcinoma develops, the process remains controversial. A key question is whether the cells of origin of the tubular… (More)
- Junchao Guo, Joerg Kleeff, +7 authors Helmut Friess
- Oncogene
- 2004
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related deaths. Deregulation of cell-cycle control is thought to be a crucial event in malignant transformation, and… (More)
- Xiao Du, Yupei Zhao, +5 authors Ya Hu
- Pancreas
- 2011
OBJECTIVE
To investigate the clinical feature and treatment strategy of primary pancreatic lymphoma.
METHODS
Thirty-nine cases of primary pancreatic lymphoma reported in China were reviewed… (More)
- Quan Liao, Junchao Guo, +4 authors Helmut Friess
- Gastroenterology
- 2003
BACKGROUND & AIMS
In both pancreatic cancer and chronic pancreatitis, there is enhanced expression of mitogenic growth factors and their tyrosine kinase receptors, which have the capacity to activate… (More)
- Yupei Zhao, Songjie Shen, +7 authors Po Sing Leung
- The Journal of surgical research
- 2006
BACKGROUND
Chemoresistance is an important clinical problem in pancreatic cancer. As the mitogen-activated protein kinases (MAPKs) have been found to be involved in the development of chemoresistance… (More)
- Junchao Guo, Joerg Kleeff, +6 authors Helmut Friess
- International journal of molecular medicine
- 2006
Pancreatic ductal adenocarcinoma (PDAC) is characterized by multiple alterations in the TGF-beta signaling pathway. Yes-associated protein (YAP65) interacts with Smad7 thereby influencing TGF-beta… (More)
- Xu Zhang, Shuai Huang, +4 authors Yupei Zhao
- International journal of oncology
- 2016
The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid… (More)
- Yatong Li, Menghua Dai, +9 authors Yupei Zhao
- Medicine
- 2016
INTRODUCTION
The aim of this study was to report a new case of mixed serous neuroendocrine neoplasm (MSNN) and review the literature concerning this type of lesion, which was added to the World… (More)
- J Li, Joerg Kleeff, +4 authors Helmut Friess
- Molecular Cancer
- 2003
BackgroundPancreatic cancer is an aggressive malignancy characterized by low responsiveness to chemotherapy and radiotherapy. This resistance is partly due to the overexpression of several tyrosine… (More)