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Synthesis and biodistribution of a novel 99mTc-DMSA-metronidazole ester as a potential tumor hypoxia imaging agent
The tumor cell experiment and the biodistribution in mice bearing S 180 tumor showed that the 99mTc-DMSAMe complex had a certain hypoxic selectivity and accumulated in the tumor with high uptake and good retention, suggesting it would be a possible tumor hypoxia imaging agent.
Preparation and bioevaluation of 99mTc nitrido radiopharmaceuticals with pyrazolo[1,5-a]pyrimidine as tumor imaging agents
Biodistribution in tumor-bearing mice demonstrated that the three new complexes showed high tumor-to-muscle (T/M) ratios and rapid clearance from the blood, muscle, liver, kidney, and lung.
Development of radiolabeled compounds for myocardial perfusion imaging.
- Xiao Lin, Junbo Zhang, Xuebin Wang, Zhi-gang Tang, Xianzhong Zhang, Jie Lu
- Biology, MedicineCurrent pharmaceutical design
- 29 February 2012
The development of various radiotracers for myocardial perfusion Imaging, including single photon emission computed tomography (SPECT) perfusion imaging agents and positron emission tomographic (PET) perfusions imaging agents are summarized and novel basic research data related to this area is introduced.
Synthesis and biological evaluation of novel 99mTc-labeled palbociclib derivatives targeting cyclin-dependent kinase 4/6 (CDK4/6) as potential cancer imaging agents.
- Xiaoqing Song, Qianqian Gan, Xuran Zhang, Junbo Zhang
- Chemistry, BiologyMolecular pharmaceutics
- 19 August 2019
Four novel 99mTc-labeled radiotracers with high radiochemical purity, good stability in vitro and high affinity for CDK4/6 have the potential for tumor imaging.
Synthesis and biodistribution of a novel (99m)TcN complex of ciprofloxacin dithiocarbamate as a potential agent for infection imaging.
Synthesis and biological evaluation of a novel 99mTc(CO)3 complex of ciprofloxacin dithiocarbamate as a potential agent to target infection.
Preparation and evaluation of 99mTc-labeled HYNIC-palbociclib analogs for cyclin-dependent kinase 4/6-positive tumor imaging.
Evaluation of 99mTc-CN5DG as a broad-spectrum SPECT probe for tumor imaging
Synthesis and biological evaluation of a novel (99m)Tc nitrido radiopharmaceutical with deoxyglucose dithiocarbamate, showing tumor uptake.