Jun-ichi Azumi

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Sequence analysis of the hypervariable regions (HVRs) of mitochondrial DNA (mtDNA) are routinely performed in forensic casework, however, there are still issues to be resolved, such as the existence of multiple errors in published databases or the limitations of individual discrimination in certain populations. Here, we analyzed the coding region of mtDNA(More)
Sequence analysis of HV2 in mitochondrial DNA has been performed as a tool for forensic identification, in addition to that of HV1. HV2 contains length heteroplasmy, which shows high variability within an individual or in maternal relatives. In this study, we used cloning analysis and PCR direct sequencing to compare, between mothers and their children, HV2(More)
SummaryThe size of C-positive qh regions of chromosomes 1, 9 and 16 was determined using a Nikon-Vickers M85 microdensitometer. Results (area) were expressed based on how different they were from an average of each 1qh, 9qh or 16qh region in terms of standard deviations (SD). It was proposed that a variant within ±1 SD of an average be assigned to the(More)
A 41-year-old woman died of subarachnoid hemorrhage. She had had severe headaches for 10 days, but no abnormalities were detected on the brain computer tomography (CT) taken about a half day prior to her death. At autopsy, bilateral dissecting aneurysms were found in the intracranial vertebral arteries. Headaches related to dissection are considered to be(More)
The frequencies of the Sydney line and the simian line on the palms of 694 normal Japanese subjects (500 males and 194 females), 180 with Down's syndrome (113 males and 67 females) and 107 with mental retardation (62 males and 45 females) were studied and the following conclusions were obtained: the frequency of the Sydney line tends to be lower in normal(More)
Loxoprofen sodium (sodium 2[4-(2-oxocyclopentylmethyl) phenyl] dehydrate; CAS #68767-14-6) is a nonsteroidal, inflammatory drug marketed only in Japan. A case report describes its association with an acute asthmatic death with features resembling those evoked by similar drugs. The analytic methodology is reported. The blood levels of loxoprofen were in the(More)
A 4-year-old child was found dead in her house. She had been suffering from insulin-dependent diabetes mellitus (IDDM) for 3 years. She had been admitted to hospital three times, and attended the hospital once a month. Her glycaemic control remained poor. Autopsy findings revealed a remarkably fatty liver and lack of beta cells in the pancreatic islets of(More)
SummaryChromosome studies were carried out in 110 patients with cleft lip and/or cleft palate. Major chromosome abnormalities were found in four cases (3.6%). They included two cases of 46, XX, 4p−, one case of 47,XY, +21 and one case of 46,XX, inv(1) (p32q12). The incidence of chromosome abnormalities in patients with cleft lip and/or cleft palate was(More)
We performed an autopsy on a frozen newborn infant who was found in a freezer at -18 degrees C. After thawing, froth emerged from the nostrils and was present in the trachea. Sometimes froth may be seen in the air-passage in cases of strangulation and drowning. In our case, however, there was neither proof of asphyxia due to strangulation nor drowning. The(More)