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OBJECTIVES To: (1) investigate the clinical efficacy of acellular dermal matrix allograft to achieve increased peri-implant keratinized mucosa around implants, and (2) evaluate the effect as to whether the increase of keratinized mucosa has a positive effect on oral hygiene. MATERIALS AND METHODS There were 10 male patients, ranging from 43 to 53 years of(More)
OBJECTIVE The purpose of this study was to investigate the root/number of roots and morphology of mandibular premolars and molars in a Korean population, and to evaluate the prevalence of three-rooted mandibular first molars having distolingual (DL) roots, three-rooted mandibular second molars, and C-shaped roots in mandibular second molars. METHODS(More)
Ongoing research has gradually recognized and understood the importance of adipose tissue (AT) angiogenesis as a key modulating factor of adipogenesis in the development of obesity. Previously, we carried out the first in vitro demonstration of the down-regulation of hypoxic angiogenesis during adipogenesis using cell-permeable chemical conjugates composed(More)
Mineral trioxide aggregate (MTA) has shown potential as a repair material for perforations. This clinical case demonstrates that when MTA was used as a repair material for root perforation due to invasive cervical resorption, the tooth was well in function for 27 months. Both clinical and radiographic follow-up showed a stable condition without any probing(More)
BACKGROUND Statin is a specific inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme involved in the cholesterol synthesis pathway. In addition to their long-known efficacy for lowering cholesterol, statins have also been reported to possess anabolic effects on bone. Simvastatin is reported to increase cancellous(More)
Tetracyclines, including tetracycline (TC), minocycline (MINO), and doxycycline (DOXY), were widely used as topical therapy in treating periodontitis, which is an infectious disease of the gingival crevice caused by periodontopathic bacteria. In addition, TC is used during bone grafting procedures because of its anticollagenase activity, antibacterial(More)
Enhancing cocaine metabolism by administration of cocaine esterase (CocE) has been considered as a promising treatment strategy for cocaine overdose and addiction, as CocE is the most efficient native enzyme yet identified for metabolizing the naturally occurring cocaine. A major obstacle to the clinical application of CocE, however, lies in its(More)
Activation of protein kinase C (PKC) by bryostatin-1 affects various functions of the central nervous system. We explored whether bryostatin-1 influenced synaptic plasticity via a process involving PKC. Our purpose was to examine whether bryostatin-1 affected the induction of hippocampal long-term potentiation (LTP) in Schaffer-collateral fibers (CA1(More)
BACKGROUND Recombinant human bone morphogenetic protein (rhBMP)-2 has been shown to stimulate significant regeneration of alveolar bone and cementum in periodontal defects clinically. The aim of this study was to evaluate the osteopromotive effect of oligopeptide domain-coated bovine bone mineral granules in a rabbit calvarial defect model. METHODS The(More)
2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) is an alternative base-labile N(alpha)-protecting group to 9-fluorenylmethoxycarbonyl (Fmoc) for amino acids. The UV spectrum of the Nsc group exhibits moderate absorption at 380 nm which is excellent for real-time monitoring of the deprotection process. It also decreases the rearrangement of X-Asp, which can be(More)