• Publications
  • Influence
Dynamic m6A mRNA methylation directs translational control of heat shock response
TLDR
The elucidation of the dynamic features of 5′UTR methylation and its critical role in cap-independent translation not only expands the breadth of physiological roles of m6A, but also uncovers a previously unappreciated translational control mechanism in heat shock response.
Dynamic m6A methylation facilitates mRNA triaging to stress granules
TLDR
It is discovered that in response to oxidative stress, transcripts are additionally m6A modified in their 5′ vicinity, and this methylation pattern provides a selective mechanism for triaging mRNAs from the translatable pool to stress-induced stress granules.
A mRNA methylation directs translational control of heat shock response
TLDR
The elucidation of the dynamic features of 59UTR methylation and its critical role in cap-independent translation not only expands the breadth of physiological roles of mA, but also uncovers a previously unappreciated translational control mechanism in heat shock response.
Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates
TLDR
‘m6A editing’ is reported, a powerful approach that enables m6A installation and erasure from cellular RNAs without changing the primary sequence and facilitates mechanistic understanding of epitranscriptome.
...
...