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Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury
This review alerts pharmaceutical companies, research institutions, and regulatory agencies to the continuing need for reliable biomarkers of EC activation in drug development.
Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
- Yuzhao Zhou, V. Vaidya, P. Goering
- Biology, MedicineToxicological sciences : an official journal of…
Urinary Kim- 1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs.
Role of ROS and Nutritional Antioxidants in Human Diseases
The potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages are highlighted.
Evaluation of miR-216a and miR-217 as potential biomarkers of acute pancreatic injury in rats and mice
- David Goodwin, B. Rosenzweig, R. Rouse
- Biology, MedicineBiomarkers : biochemical indicators of exposure…
- 19 August 2014
Pancreas-selective microRNAs were found to be relatively sensitive serum biomarkers of pancreatic injury in rodents with potentially greater specificity than the current standard assays.
Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats
- E. Herman, Jun Zhang, D. Chadwick, V. Ferrans
- Biology, ChemistryCancer Chemotherapy and Pharmacology
Compared to dexrazoxane, amifostine provided a comparable degree of protection against the nephrotoxicity of doxorubicin, but was less cardioprotective and did not prevent the mortality and loss of body weight produced by doxorbicin.
The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity
The present study showed that DRZ significantly attenuates the cardiotoxicity induced by DXR and MTX, and that this protective activity can be assessed by morphological evaluation of cardiac tissues and by monitoring the concentrations of cTnT in serum.
Biomarkers of endothelial cell activation: candidate markers for drug-induced vasculitis in patients or drug-induced vascular injury in animals.
Isoproterenol-induced Cardiotoxicity in Sprague-Dawley Rats: Correlation of Reversible and Irreversible Myocardial Injury with Release of Cardiac Troponin T and Roles of iNOS in Myocardial Injury
- Jun Zhang, A. Knapton, S. Lipshultz, J. Weaver, E. Herman
- Biology, MedicineToxicologic pathology
- 1 February 2008
It is suggested that low doses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury.
Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.
- R. Rouse, Jun Zhang, Sharron R Stewart, B. Rosenzweig, P. Espandiari, N. Sadrieh
- Biology, MedicineKidney international
- 1 June 2011
Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury and renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery.
Interstitial Dendritic Cells of the Rat Heart Quantitative and Ultrastructural Changes in Experimental Myocardial Infarction
- Jun Zhang, Zu-Xi Yu, S. Fujita, Maria L. Yamaguchi, V. Ferrans
- Medicine, BiologyCirculation
- 1 March 1993
These findings suggest that interstitial dendritic cells migrate to the myocardial infarction border zone and participate in the activation of lymphocytes and in the initiation of immune responses and decrease in number as inflammation subsides and scarring develops.