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Acoustic or sound noise due to gradient pulsing has been one of the problems in magnetic resonance imaging (MRI), both in patient scanning as well as in many areas of psychiatric and neuroscience research such as functional MRI. Our recent observations in functional MRI for the visual and motor cortex show very different results with sound noise in(More)
The present work was designed to explore the feasibility and efficacy of articular cartilage repair using composites of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) and four different hydrogels in a rat model. Full-thickness articular cartilage defects were created at the trochlear groove of femur in both knees of rats. Composites(More)
Curcumin has been shown to mitigate cancer phenotypes such as invasive migration, proliferation, and survival by disrupting numerous signaling pathways. Our previous studies showed that curcumin inhibits integrin β4 (ITG β4)-dependent migration by blocking interaction of this integrin with growth factor receptors in lipid rafts. In the current study, we(More)
e define a novel mechanism by which integrins regulate growth factor expression and the survival of carcinoma cells. Specifically, we demonstrate that the ␣ 6 ␤ 4 integrin enhances vascular endothelial growth factor (VEGF) translation in breast carcinoma cells. The mechanism involves the ability of this integrin to stimulate the phosphorylation and(More)
The exterior of the mammalian brain--the cerebral cortex--has a conserved layered structure whose thickness varies little across species. However, selection pressures over evolutionary time scales have led to cortices that have a large surface area to volume ratio in some organisms, with the result that the brain is strongly convoluted into sulci and gyri.(More)
A new approach to silent MR imaging using a rotating DC gradient has been explored and experimentally studied. Acoustic or sound noise has been one of the problems in examining patients, mainly due to the fast gradient pulsings in interaction with the main magnetic field. The sound noise has been noted to be proportionately louder as the magnetic field(More)
The human finger is exquisitely sensitive in perceiving different materials, but the question remains as to what length scales are capable of being distinguished in active touch. We combine material science with psychophysics to manufacture and haptically explore a series of topographically patterned surfaces of controlled wavelength, but identical(More)
Inspired by the observation that many naturally occurring adhesives arise as tex-tured thin films, we consider the displacement-controlled peeling of a flexible plate from an incision-patterned thin adhesive elastic layer. We find that crack initiation from an incision on the film occurs at a load much higher than that required to propagate it on a smooth(More)
Two buckling modes have been observed in thin films: buckle delamination and wrinkling. This letter identifies the conditions for selecting the favored buckling modes for elastic films on elastic substrates. Transition from one buckling mode to another is predicted as the stiffness ratio between the substrate and the film or is predicted for variation of(More)
* The rapid growth of the human cortex during development is accompanied by the folding of the brain into a highly convoluted structure 1–3. Recent studies have focused on the genetic and cellular regulation of cortical growth 4–8 , but understanding the formation of the gyral and sulcal convolutions also requires consideration of the geometry and physical(More)