Jun Yoshinaga

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OBJECTIVES Concerns over dietary exposure to bisphenol A (BPA), an endocrine disruptor, have been raised because BPA is contained in resins and plastics commonly used for the preservation of food and beverages. The purpose of the present study was to assess daily intake levels of BPA in a group of male subjects by measuring total urinary BPA (free BPA plus(More)
Element concentrations in ribs obtained from elderly Japanese people (17 males and 28 females; mean age, 81.5 years) were determined by atomic absorption spectrometry (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES), and ICP mass spectrometry (ICP-MS). Nine elements--Na, Mg, P, K, Ca, Fe, Zn, Sr, and Pb--were determinable in most of(More)
Phthalate esters and phosphate esters in samples of indoor air from 27 houses in the Tokyo Metropolitan area were quantified using gas chromatograph/mass spectrometer and gas chromatograph/flame photometric detector after adsorption on to charcoal and solvent extraction. The median concentrations of diethyl phthalate, dibutyl phthalate (DBP), butylbenzyl(More)
OBJECTIVES Our objectives were (1) to evaluate whether single spot urine is suitable media for longer-term phthalate esters exposure assessment, and (2) to estimate intake level of phthalate esters of Japanese pregnant women using urinary metabolites as an indicator of prenatal exposure level in their offspring. METHODS We analyzed nine metabolites (MMP,(More)
The purpose of this study was to investigate the relationship between the levels of prenatal exposure to phthalate ester and PAHs and birth outcomes among 149 Japanese pregnant women. Urinary concentrations of 9 phthalate ester metabolites, mono methyl phthalate (MMP), mono ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono benzyl phthalate (MBzP),(More)
Twenty elements (Al, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, P, Pb, Sr, Ti, V, Zn, C and N) in 42 Japanese ribs (forensic medical autopsy cases) were determined using inductively coupled plasma atomic emission spectrometry (ICP-AES), atomic absorption spectrometry (AAS) and carbon and nitrogen analysis to examine sex- and age-related variation in the(More)
Urinary excretion of free and total (free plus conjugated) forms of methyl, ethyl, n-propyl and n-butyl parabens (MP, EP, PP and BP, respectively) and their metabolite p-hydroxybenzoic acid were measured for 111 pregnant Japanese women. Frequent detection of parabens and their metabolite indicated that exposure takes place daily for pregnant Japanese women.(More)
This study estimated the dietary intakes of 25 pairs of Japanese children and their parents to 12 toxic and essential trace elements using 7-day duplicate diet composites. The estimated intakes of lead (children = 5.34 microg day-1, adults = 6.74 microg day-1) and tin (162 and 152 microg day-1) were below tolerable limits, but large difference in aluminium(More)
The carcinogenic activity of bisphenol A (BPA) is responsible for stimulating growth in estrogen-dependent breast cancer tissues, cell lines and rodent studies. However, it is not fully understood how this compound promotes mammary carcinogenesis. In our study, we examined the effect of BPA on cellular proliferation and senescence in human mammary(More)
OBJECTIVE The daily bisphenol A (BPA) intake level of Japanese pregnant women was surveyed based on the measurement of the urinary excretion level of a BPA metabolite. METHODS Spot urine samples were collected from 56 pregnant women who visited the gynecology division of a hospital for a routine health check between June and October 2003. The urinary(More)