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Posttranslational histone modifications play important roles in transcription and other chromatin-based processes. Compared to acetylation, methylation, and phosphorylation, very little is known about the function of histone ubiquitylation. Here, we report the purification and functional characterization of a histone H3 and H4 ubiquitin ligase complex,(More)
BACKGROUND In the past decade, there has been increasing breast reconstructions after mastectomy. The ideal material for reconstruction of a breast is fat and skin. The transverse rectus abdominis myocutaneous (TRAM) flap has been the gold standard for breast reconstruction until recently. Abdominal wall function is a major concern for plastic surgeons in(More)
Integrated HIV-1 genomes are found within actively transcribed host genes in latently infected CD4(+) T cells. Readthrough transcription of the host gene might therefore suppress HIV-1 gene expression and promote the latent infection that allows viral persistence in patients on therapy. To address the effect of host gene readthrough, we used homologous(More)
Small-animal models are useful for the in vivo study of particle-induced osteolysis, the most frequent cause of aseptic loosening after total joint replacement. Microstructural changes associated with particle-induced osteolysis have been extensively explored using two-dimensional (2D) techniques. However, relatively little is known regarding the 3D dynamic(More)
Information about the world is often represented in the brain in the form of topographic maps. A paradigm example is the topographic representation of the visual world in the optic tectum/superior colliculus. This map initially forms during neural development using activity-independent molecular cues, most notably some type of chemospecific matching between(More)
In 40 patients undergoing total hip arthroplasty with the Mayo femoral stem we studied how preoperative digital templating corresponded to the actual intraoperative choice of implant size, position, offset and restoration of leg length. The preoperatively planned sizes of the components showed a high rate of coincidence with the sizes used intraoperatively(More)
Three bacterial strains capable of transforming pyrazosulfuron-ethyl, designated as D61, D66, and D713, were isolated from pyrazosulfuron-ethyl contaminated soils. According to the sequence analysis of the partial 16S rRNA gene, it is found that the strains D61 and D66 belong to Pseudomonas sp., and the strain D713 belongs to Bacillus sp. The effects of(More)
To reutilize rice straw generated during the agricultural production process, the actinomycete strain C-5 was isolated from soil that was under the stook for several years in the Heilongjiang province of China by using multiple selective culture media. Strain C-5 was identified as Streptomyces griseorubens by China General Microbiological Culture Collection(More)
BACKGROUND Although many case-control and experimental studies have shown that highly salted foods are risk factors for stomach cancer, only a few cohort studies have supported the relationship. METHODS In a cohort study conducted in a rural area of Japan, 8035 residents aged over 30 years (approx. 55% were female) filled out a questionnaire. Seventy-six(More)