Jun‐Xiu Lu

Learn More
Circadian rhythm in the behavioral responsiveness to the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was studied in rats. Rats were subcutaneously injected with 8-OH-DPAT at one of the following times of day: 0000, 0400, 0800, 1200, 1600, 2000 hours. The post-synaptic 5-HT1A receptor behavioral syndrome, that is,(More)
In order to elucidate whether a circannual rhythm exists in the function of the central serotonin (5-HT) system, we examined the responsiveness of rats to a selective 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), at different hours of the day in different seasons. The results indicate that both a circadian rhythm and a circannual(More)
In a recent study, we found a circadian rhythm in the response of central serotonin (5-HT)1A receptors to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In the present study, the 8-OH-DPAT-induced 5-HT behavioural syndrome was examined in rats kept under continuous dark (DD) conditions for 6 days. The results revealed a circadian rhythm in the(More)
In a recent study, we observed circadian rhythms in the response to subcutaneous (s.c.) administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)1A receptor agonist, in rats. Although these results suggested a circadian rhythm in the function of the central 5-HT1A receptor, it was not possible to completely exclude drug(More)
The present study investigated the circadian variation in the behavioral response to the selective 5-HT2A/2C receptor agonist (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI). Rats were subcutaneously injected with DOI at 0000, 0400, 0800, 1200, 1600, or 2000 hours. The wet-dog shake (WDS) response was counted following administration(More)
In a recent study, we found a circadian rhythm in the serotonin (5-HT) syndrome (forepaw treading, head weaving, and flat body posture) in the response to the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). The present study examined the rhythm in the responsiveness to 8-OH-DPAT by observing hypothermia, another index of the(More)
Vascular dementia, being the most severe form of vascular cognitive impairment (VCI), is caused by cerebrovascular disease. Whether organophosphorus causes VCI remains unknown. Isocarbophos (0.5 mg/kg per 2 days) was intragastrically administrated to rats for 16 weeks. The structure and function of cerebral arteries were assayed. The learning and memory(More)
  • 1