Learn More
There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of(More)
Histone modifications play a vital role in the con-formation and function of their associated chromatin templates [1]. Histone H3K27 methylation mediated by the PRC2 complex is critical for transcriptional regulation , Polycomb silencing, Drosophila segmentation, mammalian X inactivation and cancer [1]. Interestingly, H3K27me1 (H3 mono-methylated at residue(More)
Two copies of each core histone exist in every nucleosome; however, it is not known whether both histones within a nucleosome are required to be symmetrically methylated at the same lysine residues. We report that for most lysine methylation states, wild-type histones paired with mutant, unmethylatable histones in mononucleosomes have comparable methylation(More)
Occupational cohort and case-control studies suggest that trichloroethylene (TCE) exposure may be associated with non-Hodgkin lymphoma (NHL) but findings are not consistent. There is a need for mechanistic studies to evaluate the biologic plausibility of this association. We carried out a cross-sectional molecular epidemiology study of 80 healthy workers(More)
Projected changes in the frequency and severity of droughts as a result of increase in greenhouse gases have a significant impact on the role of vegetation in regulating the global carbon cycle. Drought effect on vegetation Gross Primary Production (GPP) is usually modeled as a function of Vapor Pressure Deficit (VPD) and/or soil moisture. Climate(More)
Deconvolution wide-field fluorescence microscopy and single-particle tracking were used to study the three-dimensional mobility of single secretory granules in live PC12 cells. Acridine orange-labeled granules were found to travel primarily in random and caged diffusion, whereas only a small fraction of granules traveled in directed fashion. High K(+)(More)
Epidemiological studies suggest that trichloroethylene (TCE) exposure may be associated with renal cancer. The biological mechanisms involved are not exactly known although nephrotoxicity is believed to play a role. Studies on TCE nephrotoxicity among humans, however, have been largely inconsistent. We studied kidney toxicity in Chinese factory workers(More)