TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis
- P. Boström, Jun Wu, B. Spiegelman
- Biology
- 2012
It is shown that PGC1 α expression in muscle stimulates an increase in expression of Fndc5, a membrane protein that is cleaved and secreted as a new hormone, irisin, which results in improvements in obesity and glucose homeostasis.
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- Jun Wu, P. Boström, B. Spiegelman
- BiologyCell
- 20 July 2012
A PGC1α-dependent myokine that drives browning of white fat and thermogenesis
- P. Boström, Jun Wu, B. Spiegelman
- BiologyNature
- 11 January 2012
It is shown in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin, which results in improvements in obesity and glucose homeostasis.
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
- F. Fisher, Sandra Kleiner, B. Spiegelman
- BiologyGenes & Development
- 1 February 2012
It is shown here that fibroblast growth factor 21 (FGF21) plays a physiologic role in this thermogenic recruitment of WATs and acts to activate and expand the thermogenic machinery in vivo to provide a robust defense against hypothermia.
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.
- C. Wrann, James P White, B. Spiegelman
- BiologyCell Metabolism
- 5 November 2013
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
- D. Rutkowski, S. M. Arnold, R. Kaufman
- BiologyPLoS Biology
- 1 November 2006
This work provides new insight into how a stress response pathway can be structured to allow cells to avert death as they adapt and underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome.
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
- Kezhong Zhang, Xiaohua Shen, R. Kaufman
- BiologyCell
- 10 February 2006
ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.
- Jun Wu, D. Rutkowski, R. Kaufman
- BiologyDevelopmental Cell
- 4 September 2007
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