Jun Toriumi

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We have previously detected a single base substitution of G by A at the Arg codon CGC in exon 4 of the mutant lactate dehydrogenase (LDH) gene, an unstable LDH-B variant (case 1). Here, we use the polymerase chain reaction (PCR) to amplify genomic DNA of two cases (the original case 1 and a new patient, case 2). We were able to confirm that case 1 is(More)
An electrophoretic variant of lactate dehydrogenase-A (M) subunit was discovered in a patient with multiple myeloma. DNA analysis of the variant allele revealed a nucleotide substitution (transition) of C to T at codon 314 (CGT-TGT), and this mutation resulted in the replacement of an arginine by a cysteine (R314C). This amino acid replacement affects the(More)
patients had fever and ascites was observed on 16 patients in which bloody ascites was prooved in 10 cases. Jaundice also appeared on 16 patients. Abdominal pain was severe in patients who had remarkable hemorrhage and necrosis of the liver and there were no distinct relations between abdominal pain and weight of the liver, extention and metastasis of the(More)