Leptin is a circulating molecule for the regulation of food intake and body weight suggested to be mediated in the hypothalamus via Ob-Rb receptor, which activates Janus kinase-signal transducer and activator of transcription (STAT) pathways. Although leptin receptors exist in many regions of the brain, there have been few in vivo functional studies of… (More)
The senescence-accelerated mouse (SAM) is known as a murine model for accelerated aging. The SAMP8 shows age-related deficits of learning and memory at an earlier age than control mice (SAMR1). We investigated the changes in oligodendrocytes in the brain of SAMP8, using immunohistochemistry for myelin basic protein (MBP) and 2',3'-cyclic nucleotide… (More)
Reduced food intake brings about an adaptive decrease in energy expenditure that contributes to the recidivism of obesity following weight loss. Insulin and leptin inhibit food intake through actions in the central nervous system that are partly mediated by FoxO1. We show that FoxO1 ablation in pro–opiomelanocortin (Pomc) neurons (Pomc–Foxo1 −/−) reduces… (More)
The authors propose the use of a pinching gesture for relating the applications running on discrete mobile devices. The gesture is realized by swiping the touch-screen of two annexed mobile devices as if pinching them together. The authors believe that this user interface can create new user experiences of multiple-screen usages, especially by designing the… (More)
OBJECTIVE Atherosclerotic cardiovascular disease is the leading cause of death among people with diabetes. Generation of oxidized LDLs and reduced nitric oxide (NO) availability because of endothelial NO synthase (eNOS) dysfunction are critical events in atherosclerotic plaque formation. Biochemical mechanism leading from hyperglycemia to oxLDL formation… (More)
We designed and built a system that configures the information of how displays are arranged as a multi-display environment. The system automatically matches the physical location of displays and network addresses. It uses a web camera for capturing a real-time video to observe each display to flash its screens one by one. The timing and relative locations… (More)
We developed MovieTile, a system for constructing multi-display environments using multiple mobile devices. The system offers a simple and intuitive interface for configuring a display arrangement. It enables the use of devices of different screen sizes mixed in forming a single virtual screen of free shape. The system delivers a movie file to all devices,… (More)
Starting with a σ-finite measure on an algebra, we define a pseu-dometric and show how measurable sets from the Caratheodory Extension Theorem can be thought of as limit points of Cauchy sequences in the algebra.