Asuka Morizane15
Nobuo Hashimoto13
Keijiro Mukaiyama12
Hiroyuki Hashidate12
15Asuka Morizane
13Nobuo Hashimoto
12Keijiro Mukaiyama
12Hiroyuki Hashidate
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Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for cell-replacement therapy in PD. We previously described a strong neuralizing activity present on the surface of stromal cells, named stromal cell-derived inducing activity (SDIA).(More)
Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of access to motor neurons from ALS patients and appropriate disease models. We generate motor neurons from induced pluripotent stem cells (iPSCs) from familial ALS patients, who(More)
Extract: The most common neurodegenerative movement disorder in man is Parkinson's disease (PD) and it is characterized by the loss of midbrain dopaminergic neurons in the substantia nigra of the brain. The loss of these neurons, which normally project to the striatum, also causes a decrease in striatal dopamine levels. While being the precursor to dopamine(More)
Embryonic stem (ES) cells differentiate into neuroectodermal progenitors when cultured as floating aggregates in serum-free conditions. Here, we show that strict removal of exogenous patterning factors during early differentiation steps induces efficient generation of rostral hypothalamic-like progenitors (Rax(+)/Six3(+)/Vax1(+)) in mouse ES cell-derived(More)
BACKGROUND Different perforation rates for cervical pedicle screws by disease are expected in relation to bone quality and pedicle morphology; however, no report comparing pedicle screw perforation rate by disease had previously been published. This study investigated the perforation rates of pedicle screws inserted to cervical pedicle by disease and(More)
To investigate the effect of estrogen on neuronal differentiation, especially on dopaminergic (DA) neurons, human neural stem cells (NSCs) were differentiated in the presence of 17beta-estradiol. NSCs gave rise to tyrosine hydroxylase (TH)-positive neurons in vitro, the proportion of which was increased by 17beta-estradiol. Increase in TH-positive neurons(More)
  • Kenji Tanigaki, Fumiaki Nogaki, Jun Takahashi, Kei Tashiro, Hisanori Kurooka, Tasuku Honjo
  • 2001
Notch1 has been shown to induce glia in the peripheral nervous system. However, it has not been known whether Notch can direct commitment to glia from multipotent progenitors of the central nervous system. Here we present evidence that activated Notch1 and Notch3 promotes the differentiation of astroglia from the rat adult hippocampus-derived multipotent(More)
Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using cells derived from a patient's own cells. However, the immunogenicity of iPSCs or their derivatives has been a matter of controversy, and up to now there has been no direct comparison of autologous and allogeneic transplantation in the brains of humans or(More)
Transplantation of stem cells has the possibility of restoring neural functions after stroke damage. Therefore, we transplanted neuronal progenitors generated from monkey embryonic stem (ES) cells into the ischemic mouse brain to test this possibility. Monkey ES cells were caused to differentiate into neuronal progenitors by the stromal cell-derived(More)
—In this paper, we propose and evaluate an anticipatory stigmergy model for traffic management. Recently, dynamic coordination methods are becoming possible using the more short-term traffic information that can be provided by probe-vehicle information or smart phones. Some approaches have been trying to handle short-term traffic information in which a(More)