Jun Suzurikawa

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In this study we present a novel imaging method that combines high resolution cerebral blood flow imaging with a highly flexible map of absolute pO 2. In vivo measurements of pO 2 in animals using phosphorescence quenching is a well established method, and is preferable over electrical probes which are inherently invasive and are limited to single point(More)
Individual neurons are heterogeneous and have profound impact on population activity in a complex cortical network. Precise experimental control of the firing of multiple neurons would be therefore beneficial to advance our understanding of cell-network interactions. Except for direct intracellular stimulation, however, it is difficult to gain precise(More)
This paper provides a detailed process flow for fabricating an easy-to-prepare, inexpensive, dense array of tungsten microelectrodes. We designed the process flow to minimize routine tasks by separating an initial preparation of a master mold from a routine preparation of substrate replication, array assembly and tip processing. Sandblast processing first(More)
Light addressing is an emerging and sophisticated technique that can induce pinpoint and/or patterned neuronal activation in cultured neurons. We previously developed a light-addressable electrode using hydrogenated amorphous silicon (a-Si:H), which was sandwiched between a tin oxide (SnO(2)) substrate and a passivation layer of zinc antimonate(More)
Recently, intrinsic signal optical imaging has been widely used as a routine procedure for visualizing cortical functional maps. We do not, however, have a well-established imaging method for visualizing cortical functional connectivity indicating spatio-temporal patterns of activity propagation in the cerebral cortex. In the present study, we developed a(More)
INTRODUCTION In order to electrochemically and/or electrophysiologically monitor in-situ activities of cultured cells adhering on a substrate, micro-electrode arrays (MEAs) patterned on the substrate have been utilized. MEAs allow non-invasive and multisite monitoring with the fine temporal resolution. However, the spatial resolution of MEAs is limited by(More)
Electrical stimulation that can reorganize our neural system has a potential for promising neurorehabilitation. We previously demonstrated that temporally controlled intracortical microstimulation (ICMS) could induce the spike time-dependant plasticity and modify tuning properties of cortical neurons as desired. A 'pairing' ICMS following tone-induced(More)
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