Jun - Sub Choi

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PURPOSE To investigate the anti-angiogenic effect of topical curcumin on corneal neovascularization in a rabbit model. MATERIALS AND METHODS One week after suturing, six eyes were treated with balanced salt solution (BSS) (group A), and six eyes were treated with curcumin 40, 80, or 160 micromol/L (groups B, C, and D, respectively), topically two times a(More)
Choroidal neovascularization (CNV) is the defining characteristic feature of the wet subtype of age-related macular degeneration (AMD) and may result in irreversible blindness. Based on anti-vascular endothelial growth factor (anti-VEGF), the current therapeutic approaches to CNV are fraught with difficulties, and mammalian target of rapamycin (mTOR) has(More)
T he endothelium lining the blood vasculature forms an interface between the blood and tissues and plays a crucial role in controlling the blood-to-tissue movement of plasma proteins, solute, and water. Under normal physiological conditions, transvascular exchange is modulated by hydrostatic and oncotic forces, the concentration gradient of solutes acting(More)
Sulfasalazine is widely used to treat inflammatory diseases. Besides anti-inflammatory actions such as blockade of nuclear factor-kappaB and cyclooxygenases, we found that 30 to 1000 micro M sulfasalazine dose dependently blocked N-methyl-D-aspartate receptor-mediated excitotoxicity without intervening kainate or(More)
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