15Jan Willem van der Veen
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Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death. Developing minimally invasive techniques that can diagnose NSCLC, particularly at an early stage, may improve its outcome. Using microarray platforms, we previously identified 12 microRNAs (miRNAs) the aberrant expressions of which in primary lung tumors are associated with(More)
Attentional dysfunction is one of the most consistent findings in individuals with autism spectrum disorders (ASD). However, the significance of such findings for the pathophysiology of autism is unclear. In this study, we investigated cellular neurochemistry with proton magnetic resonance spectroscopy imaging ((1)H-MRS) in brain regions associated with(More)
BPEL4WS is a well-established business process standard that can be used to orchestrate service-based workflows. However, the rapid growth and automation demands of e-business and grid applications require BPEL4WS to provide enhanced semantic annotations to achieve the goal of business processes automation. Here, OWLS (OWL for Web Services) is designed to(More)
With the rapid deployment of e-services, many workflow-like e-business process definition languages come into existence. At the same time, Ontology Web Language for Services (OWLS) aims to build an ontology language to support the integration of various specifications. There has been some work on mapping WSDL (Web Services Description Language) to OWLS to(More)
  • Jun Shen, Edward C. Gilmore, Christine A. Marshall, Mary Haddadin, John J. Reynolds, Wafaa Eyaid +9 others
  • 2010
Maintenance of DNA integrity is crucial for all cell types, but neurons are particularly sensitive to mutations in DNA repair genes, which lead to both abnormal development and neurodegeneration. We describe a previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted(More)
BACKGROUND Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in(More)
BACKGROUND Making a definitive preoperative diagnosis of solitary pulmonary nodules (SPNs) found by CT has been a clinical challenge. We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma microRNAs are useful in identifying lung cancer among individuals with CT-detected(More)
Business applications are more and more often developed on the basis of Web services. The aim is to provide platform independence and loose coupling between business applications to facilitate distributed and grid computing scenarios. However, most efforts to deploy and publish Web services are manual. Manual discovery, in-vocation and composition of Web(More)
Although most existing teamwork management systems support user-friendly interface to some extent, few of them have take into consideration of the special requirements of workflow visualisation. This paper realises the unique features of visualisation for run-time workflow, i.e., workflow enactment and execution. We present a detailed discussion of the(More)