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Influenza B virus hemagglutinin (HA) is a major surface glycoprotein with frequent amino acid substitutions. However, the roles of antibody selection in the amino acid substitutions of HA were still poorly understood. In order to gain insights into this important issue, an analysis was conducted on a total of 271 HA1 sequences of influenza B virus strains(More)
BACKGROUND As screening central nervous system (CNS) imaging is not routinely performed, the incidence and clinical relevance of occult CNS metastases in advanced breast cancer is unknown. PATIENTS AND METHODS All patients screened for participation in one of four clinical trials were included; each of the trials excluded patients with known CNS(More)
Hair cells of the inner ear are essential for hearing and balance. As a consequence, pathogenic variants in genes specifically expressed in hair cells often cause hereditary deafness. Hair cells are few in number and not easily isolated from the adjacent supporting cells, so the biochemistry and molecular biology of hair cells can be difficult to study. To(More)
To access the potential roles of NF-kappaB-dependent pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-6(IL-6), and interleukin-8(IL-8), in oral lichen planus (OLP), and to explore whether salivary detection of these cytokines is a better monitoring tool than serum for OLP, 30 Chinese patients with OLP and 30(More)
The inner ear is a highly specialized mechanosensitive organ responsible for hearing and balance. Its small size and difficulty in harvesting sufficient tissue has hindered the progress of molecular studies. The protein components of mechanotransduction, the molecular biology of inner ear development and the genetic causes of many hereditary hearing and(More)
PURPOSE Hypertrophic cardiomyopathy (HCM) is caused primarily by pathogenic variants in genes encoding sarcomere proteins. We report genetic testing results for HCM in 2,912 unrelated individuals with nonsyndromic presentations from a broad referral population over 10 years. METHODS Genetic testing was performed by Sanger sequencing for 10 genes from 2004(More)
With the rapid deployment of e-services, many workflow-like e-business process definition languages come into existence. At the same time, ontology Web language for services (OWL-S) aims to build an ontology language to support the integration of various specifications. There has been some work on mapping WSDL (Web services description language) to OWL-S to(More)
BPEL4WS is a well-established business process standard that can be used to orchestrate service-based workflows. However, the rapid growth and automation demands of e-business and grid applications require BPEL4WS to provide enhanced semantic annotations to achieve the goal of business processes automation. Here, OWLS (OWL for Web Services) is designed to(More)