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A fragment of HeLa cell mitochondrial DNA containing the origin of replicaton has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5'-end proximal portion of the heavy strand initiation fragment (7S DNA), and by aligning the two sequences.
In order to clarify the functional role of the isolectin B4 (IB4)-binding afferent pathway in the micturition reflex, we investigated the effects on bladder activity of intrathecal application of the IB4-saporin conjugate, a targeting cytotoxin that destroys neurons binding IB4. In rats, IB4-saporin (2.5 micro m) or vehicle was administered through an… (More)