Jun Miura-Ohnuma

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In mammals, taste buds are maintained by continuous turnover of cells, even in adulthood. Cell proliferation and differentiation continue to produce taste cells, which express various genes related to taste reception. We found the co-expression of Sonic hedgehog (Shh) with Prox1 and that of Nkx2.2 with Mash1 in adult mouse taste buds. Whereas Prox1was(More)
Introduction In mammals, taste buds arise from local epithelium and are maintained by continuous cell renewal The life span of taste cells is estimated to be ~10 days. Denervation causes the degeneration of taste buds, indicating that the taste nerves trophi-cally maintain the taste buds. It is assumed that cell proliferation, differentiation and death for(More)
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