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In this paper, we reveal a remarkable connection between the Thue-Morse sequence and the Koch snowflake. Using turtle geometry and polygon maps, we realize the Thue-Morse sequence as the limit of polygonal curves in the plane. We then prove that a sequence of such curves converges to the Koch snowflake in the Hausdorff metric. In the final section we(More)
BACKGROUND Only limited research tracks United States trends in the use of statins recorded during outpatient visits, particularly use by patients at moderate to high cardiovascular risk. METHODS AND FINDINGS Data collected between 1992 and 2002 in two federally administered surveys provided national estimates of statin use among ambulatory patients,(More)
BACKGROUND The Diabetes Prevention Program (DPP) lifestyle intervention reduced the incidence of type 2 diabetes mellitus (DM) among high-risk adults by 58%, with weight loss as the dominant predictor. However, it has not been adequately translated into primary care. METHODS We evaluated 2 adapted DPP lifestyle interventions among overweight or obese(More)
A lthough mortality for cardiovascular disease (CVD) has declined for several decades, heart disease and stroke continue to be the leading causes of death, disability, and high healthcare costs. Unhealthy behaviors related to CVD risk (eg, smoking, sedentary lifestyle, and unhealthful eating habits) remain highly prevalent. The high rates of overweight,(More)
  • Jun Ma, A. Vardy
  • 2007
Recently, Lee and O'Sullivan proposed a new interpolation algorithm for algebraic soft-decision decoding of Reed- Solomon codes. In some cases, the Lee-O'Sullivan algorithm turns out to be substantially more efficient than alternative interpolation approaches, such as Koetter's algorithm. Herein, we combine the re-encoding coordinate transformation,(More)
BACKGROUND Despite the proven benefits of aspirin therapy in the primary and secondary prevention of cardiovascular disease (CVD), utilization rates of aspirin remain suboptimal in relation to recommendations. We studied national trends of aspirin use among intermediate- to high-risk patients in the US ambulatory care settings and compared the priority(More)
BACKGROUND Although modifiable cardiovascular disease risk factors are common, some patients eschew conventional drug treatments in favor of natural alternatives. Pine bark extract, a dietary supplement source of antioxidant oligomeric proanthocyanidin complexes, has multiple putative cardiovascular benefits. Studies published to date about the supplement(More)
BACKGROUND Case management has emerged as a promising alternative approach to supplement traditional one-on-one sessions between patients and doctors for improving the quality of care in chronic diseases such as coronary heart disease (CHD). However, data are lacking in terms of its efficacy and cost-effectiveness when implemented in ethnic and low-income(More)
Medication choices for the treatment of elevated blood pressure have a large potential impact on both patient outcomes and health care costs. Historic trends of prescribing for hypertension will advance the understanding of physician practice of evidence-based medicine. This study describes both long- and short-term trends in US antihypertensive prescribing(More)
Breast cancer stem cells, the root of tumor growth, present challenges to investigate: Primary human breast cancer cells are difficult to establish in culture and inconsistently yield tumors after transplantation into immune-deficient recipient mice. Furthermore, there is limited characterization of mammary cancer stem cells in mice, the ideal model for the(More)