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Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis
TLDR
Rocaglates are a series of structurally complex secondary metabolites with considerable cytotoxicity that have been isolated from plants of the Aglaia genus (Meliaceae) and their structures were elucidated based on a joint effort of spectroscopic methods and single-crystal X-ray diffraction.
Rhodomyrtials A and B, Two Meroterpenoids with a Triketone-Sesquiterpene-Triketone Skeleton from Rhodomyrtus tomentosa: Structural Elucidation and Biomimetic Synthesis.
TLDR
Two unprecedented triketone-sesquiterpene-triketone adducts and five biogenetically related intermediates were isolated from the leaves of Rhodomyrtus tomentosa and exhibited potent metastatic inhibitory activity against DLD-1 cells by suppressing the activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Limonoids with diverse frameworks from the stem bark of Entandrophragma angolense and their bioactivities
Entangolensins A–P (1–16), sixteen new limonoids with diverse frameworks, were isolated from the stem bark of Entandrophragma angolense. Their planar structures were elucidated on the basis of
Polyprenylated Tetraoxygenated Xanthones from the Roots of Hypericum monogynum and Their Neuroprotective Activities.
TLDR
The structures of these new polyprenylated xanthones (1-10), a class of compounds rarely found in plants of the genus Hypericum, were elucidated by the interpretation of their HRESIMS, 1D and 2D NMR, and electronic circular dichroism data, and shed new light on the potential on the development of antidepression therapies.
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