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Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.
It is shown that endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear envelope and that the envelope localization ofUNC-84 requires Ce- Lamin, and that during mitosis, UNC- 84 remains at thenuclear periphery until late anaphase, similar to known inner nuclear membrane proteins.
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans
Findings show that LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery–Dreifuss muscular dystrophy.
Age-related changes of nuclear architecture in Caenorhabditis elegans.
This work found that the nuclear architecture in most nonneuronal cell types undergoes progressive and stochastic age-dependent alterations, such as changes of nuclear shape and loss of peripheral heterochromatin, and shows that the rate of these alterations is influenced by the insulin/IGF-1 like signaling pathway and that reducing the level of lamin and lamin-associated LEM domain proteins leads to shortening of lifespan.
The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm
C. elegans Myod homolog HLH-1 acts downstream of mls-2 to specify M-derived coelomocyte cell fates, and MLS-2 functions in a cell type-specific manner to regulate both cell proliferation and cell fate specification.
Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope
It is found that downregulating LPIN-1 by RNAi results in the appearance of membrane sheets and other abnormal structures in the peripheral ER, and suggests that lipid synthesis has a role in NE dynamics.
The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans
This work demonstrates that DRAG-1 is a membrane-associated protein that functions at the ligand-receptor level to modulate the Sma/Mab pathway in a cell-type-specific manner, and provides a direct link between RGM proteins and BMP signaling in vivo and a simple and genetically tractable system for mechanistic studies of RGM protein regulation of BMP pathways.
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis
ETOC: Caenorhabditis elegans lacking both Ce-emerin and LEM-2 show that these proteins are essential for development of specific lineages, mitosis in somatic cells, and smooth muscle activity.
Loss of a doublecortin (DCX)-domain protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host-cell invasion
The human pathogen Toxoplasma gondii builds a remarkable structure, the conoid, from the ubiquitous cytoskeletal protein tubulin but arranges it into a completely novel form that cripples the ability of the parasite to invade host cells.
The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans.
It is shown for the first time in any organism that nuclear lamins are essential for the nuclear envelope localization of emerin during early development and suggests that emerin is not essential to organize or localize the only lamin expressed in C. elegans.