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We introduce a missing data recovery methodology based on a weighted least squares iterative adaptive approach (IAA). The proposed method is referred to as the missing-data IAA (MIAA) and it can be used for uniform or non-uniform sampling as well as for arbitrary data missing patterns. MIAA uses the IAA spectrum estimates to retrieve the missing data, based(More)
Microsatellites are short tandem repeats of one to six bases in genomic DNA. As microsatellites are highly polymorphic and play a vital role in gene function and recombination, they are an attractive subject for research in evolution and in the genetics and breeding of animals and plants. Orphan genes have no known homologs in existing databases. Using(More)
Claudin family transmembrane proteins play an important role in tight junction structure and function in epithelial cells. Among the 24 isoforms identified in mice and humans, claudin-4 and -3 serve as the receptor for Clostridium perfringens enterotoxin (Cpe). The second extracellular loop (Ecl2) of claudin-4 is responsible for the binding to the(More)
Low probability of detection (LPD) communications are conducted at a low received signal-to-noise ratio (SNR) to deter eavesdroppers to sense the presence of the transmitted signal. Successful detection at intended receiver heavily relies on the processing gain achieved by employing the direct-sequence spread-spectrum (DSSS) technique. For scenarios that(More)
The need for achieving higher data rates in underwater acoustic communications leverages the use of multi-input multi-output (MIMO) schemes. In this paper two key issues regarding the design of a MIMO communications system, namely, channel estimation and symbol detection, are addressed. To enhance channel estimation performance, a cyclic approach for(More)
BACKGROUND Mucosal immune surveillance is thought to be largely achieved through uptake by specialized epithelial M cells. We recently identified Claudin 4 as an M cell target receptor and developed a Claudin 4 targeting peptide (CPE) that can mediate uptake of nanoparticles through Nasal Associated Lymphoid Tissue (NALT) M cells. METHODS Recombinant(More)
The precise mechanism by which glucocorticoid receptor (GR) regulates the transcription of its target genes is largely unknown. This is, in part, due to the lack of structural and functional information about GR's N-terminal activation function domain, AF1. Like many steroid hormone receptors (SHRs), the GR AF1 exists in an intrinsically disordered (ID)(More)
Mesorhizobium tianshanense employs MsiA as canavanine exporter, which is upregulated by MsiR, to successfully form a symbiosis with the legume Glycyrrhiza uralensis. In this research, through gel-shift and bacterial two-hybrid examination, MsiR was found to spontaneously form dimers and bind to msiA promoter without additional canavanine. Six truncated(More)