• Publications
  • Influence
Mechanisms of antibiotic resistance
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by a growing number of antibiotic-resistant pathogens. AntibioticExpand
  • 452
  • 31
  • PDF
CmeABC Functions as a Multidrug Efflux System in Campylobacter jejuni
ABSTRACT Campylobacter jejuni, a gram-negative organism causing gastroenteritis in humans, is increasingly resistant to antibiotics. However, little is known about the drug efflux mechanisms in thisExpand
  • 447
  • 28
CmeR Functions as a Transcriptional Repressor for the Multidrug Efflux Pump CmeABC in Campylobacter jejuni
ABSTRACT CmeABC, a resistance-nodulation-division (RND) type of efflux pump, contributes to Campylobacter resistance to a broad spectrum of antimicrobial agents and is also essential forExpand
  • 176
  • 23
Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni.
CmeABC, a multidrug efflux pump, is involved in the resistance of Campylobacter jejuni to a broad spectrum of antimicrobial agents and is essential for Campylobacter colonization in animal intestineExpand
  • 174
  • 21
  • PDF
Novel approaches for Campylobacter control in poultry.
  • Jun Lin
  • Biology, Medicine
  • Foodborne pathogens and disease
  • 8 September 2009
The Gram-negative bacterium Campylobacter is the most common bacterial cause of human gastroenteritis in the United States and many industrialized countries. Poultry, particularly chickens, isExpand
  • 168
  • 17
Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni.
OBJECTIVES To determine the role of CmeDEF in conferring antimicrobial resistance in Campylobacter jejuni and examine the interaction of CmeABC and CmeDEF in mediating antimicrobial resistance andExpand
  • 133
  • 15
Critical Role of Multidrug Efflux Pump CmeABC in Bile Resistance and In Vivo Colonization of Campylobacter jejuni
ABSTRACT CmeABC functions as a multidrug efflux pump contributing to the resistance of Campylobacter to a broad range of antimicrobials. In this study, we examined the role of CmeABC in bileExpand
  • 263
  • 13
Effect of Macrolide Usage on Emergence of Erythromycin-Resistant Campylobacter Isolates in Chickens
ABSTRACT In this work we conducted both in vitro and in vivo experiments to examine the development and mechanisms of erythromycin (Ery) resistance in Campylobacter jejuni and Campylobacter coli. InExpand
  • 93
  • 13
In Vivo Selection of Campylobacter Isolates with High Levels of Fluoroquinolone Resistance Associated with gyrA Mutations and the Function of the CmeABC Efflux Pump
ABSTRACT Enrofloxacin treatment of chickens infected with fluoroquinolone(FQ)-sensitive Campylobacter promoted the emergence of FQ-resistant Campylobacter mutants which propagated in the intestinalExpand
  • 232
  • 12
Campylobacter in Poultry: Ecology and Potential Interventions
SUMMARY Avian hosts constitute a natural reservoir for thermophilic Campylobacter species, primarily Campylobacter jejuni and Campylobacter coli, and poultry flocks are frequently colonized in theExpand
  • 105
  • 10