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OBJECTIVES Retrospective and prospective studies examined the surgical effects in lowering intraocular pressure levels of trabeculotomy ab externo in adult eyes with either primary open angle glaucoma or pseudoexfoliation syndrome. We report the results of primary trabeculotomy as an intervention for glaucoma. PATIENTS Included in the retrospective study(More)
PURPOSE To clarify clinical features and pathophysiology and to evaluate surgical outcome of subscleral sclerectomy for primary uveal effusion syndrome. DESIGN Prospective, consecutive noncomparative case series. PARTICIPANTS Nineteen eyes of 16 patients diagnosed with uveal effusion syndrome treated in our clinic between 1989 and 1998. METHODS(More)
Management of surgically induced astigmatism is an important problem for surgeons implanting intraocular lenses. Besides corneal astigmatism, the fixation status of the intraocular lens (IOL) may contribute to total astigmatism. This study was undertaken to evaluate the effect of tilt and decentration of the implanted posterior chamber IOL on the total(More)
PURPOSE To evaluate the efficacy and safety of brinzolamide 1%/timolol 0.5% fixed-combination (BRINZ/TIM-FC) therapy compared with timolol 0.5% (TIM) monotherapy in Japanese patients with open-angle glaucoma or ocular hypertension. METHODS This randomized, double-masked, multicenter study included Japanese patients aged ≥20 years. Patients were treated(More)
Free radicals are thought to be one of the causes of retinal light damage. Experiments were performed to identify the production of free radicals in light exposed retinas of rabbits using nitro blue tetrazolium (NBT) staining. In addition, a free radical scavenger, alpha-tocopherol, was administered systemically before light exposure to evaluate the(More)
Pigmented rabbits were exposed for 2 hours to xenon light to evaluate the light induced retinal damage clinicopathologically. The xenon light was passed through a heat filter to avoid the influence of long waves, and through the fundus contact lens on the cornea to avoid focusing the light on the retina. No abnormal findings were detected in the retina in(More)
We have reported previously that xenon light exposure without long waves primarily damages the retinal pigment epithelium (RPE) of pigmented rabbits. Alpha-tocopherol, which is a free radical scavenger, was administered systemically to pigmented rabbits before light exposure in order to evaluate the protective effect against retinal light damage. In(More)
PURPOSE To compare efficacy of aspherical intraocular lenses (IOLs) with spherical IOLs by measuring the ocular and internal higher-order aberrations. METHODS Two hundred four eyes of 145 patients were evaluated at Kozaki eye clinic after phacoemulsification with implantation of 2 aspherical IOLs (45 eyes with the Hoya FY60AD, and 43 eyes with the Nidek(More)
PURPOSE The time course of visual field defects in patients with primary glaucoma was investigated for 20 or more years. METHODS The subjects were 51 eyes of 29 patients (open angle glaucoma, 40 eyes of 21 patients angle closure glaucoma, 11 eyes of 8 patients). The mean intraocular pressure of these subjects was within 21 mmHg during the follow-up(More)
PURPOSE To assess the efficacy and tolerability of benzalkonium chloride (BAK)-free travoprost after transition from BAK-preserved latanoprost. METHODS This was a prospective, open-label, multicenter study in patients with open-angle glaucoma or ocular hypertension who had been treated with latanoprost monotherapy for at least 3 months. The main outcome(More)