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- Publications
- Influence
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- J. Tsai, J. T. Lee, +35 authors G. Bollag
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 26 February 2008
BRAFV600E is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting “active” protein kinases have demonstrated significant utility in the therapeutic repertoire… Expand
STMC-24. NOVEL INHIBITOR OF CDK5 SIGNALING AXIS SUPPRESSES SELF-RENEWAL PROPERTIES OF GBM STEM CELLS AND INDUCES APOPTOSIS
- Subhas Mukherjee, Monica Chau, +4 authors D. Brat
- Medicine
- 1 November 2016
Communicating about the emergy ecological footprint for a small fish farm in China
Abstract Sustainability evaluation of mariculture is needed for policy decision-making in its development. Zhao et al. (2013) developed the method of emergy ecological footprint to evaluate an… Expand
CS-23DEFINING THE NETWORKS AND INTERSECTION OF EGFR AMPLIFICATION AND NFKBIA DELETION IN HUMAN GLIOMA
Nuclear factor KappaB (NF-κB) is a critical transcriptional regulator in glioblastoma (GBM) and is normally inhibited by IKBα, the product of NFKBIA. The relative mutual exclusivity of EGFR… Expand
Abstract LB-029: Signal transduction in EGFR-amplified and NFKBIA-deleted human gliomas
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA
Nuclear factor Kappa B (NF-κB)- a nuclear transcription factor that is retained in the cytoplasm by IKBα (encoded by… Expand
Abstract 3897: Novel inhibitor of GBM stem cells targets unique CREB & Myc-mediated self-renewal pathways regulated by CDK5
- Subhas Mukherjee, C. Tucker-Burden, +4 authors D. Brat
- Medicine
- 1 July 2017
Research on the Development Strategy of the Midpoint City in “Beijing-Tianjin” Dual-Core Region Structure
The characteristics of dual-core region structure of Beijing-Tianjin and the development of their midpoint city – Langfang is analyzed and researched. It is proposed in this paper that the… Expand
Abstract LB-50: TRIM3, the human homolog of Drosophila Brat, is a tumor suppressor that regulates asymmetric cell division (ACD) in glioblastoma stem cells
- Subhas Mukherjee, G. Chen, +8 authors D. Brat
- Biology
- 1 October 2014
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
Cancer stem cells, capable of self-renewal and multipotent differentiation, influence tumor behavior through a complex balance… Expand
STEM-30. CDK5 INHIBITION RESOLVES PKA/cAMP-INDEPENDENT ACTIVATION OF CREB1 SIGNALING IN GLIOMA STEM CELLS
- Subhas Mukherjee, C. Tucker-Burden, +10 authors D. Brat
- Chemistry
- 6 November 2017