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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
BRAFV600E is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting “active” protein kinases have demonstrated significant utility in the therapeutic repertoireExpand
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Communicating about the emergy ecological footprint for a small fish farm in China
Abstract Sustainability evaluation of mariculture is needed for policy decision-making in its development. Zhao et al. (2013) developed the method of emergy ecological footprint to evaluate anExpand
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CS-23DEFINING THE NETWORKS AND INTERSECTION OF EGFR AMPLIFICATION AND NFKBIA DELETION IN HUMAN GLIOMA
Nuclear factor KappaB (NF-κB) is a critical transcriptional regulator in glioblastoma (GBM) and is normally inhibited by IKBα, the product of NFKBIA. The relative mutual exclusivity of EGFRExpand
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Abstract LB-029: Signal transduction in EGFR-amplified and NFKBIA-deleted human gliomas
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Nuclear factor Kappa B (NF-κB)- a nuclear transcription factor that is retained in the cytoplasm by IKBα (encoded byExpand
Research on the Development Strategy of the Midpoint City in “Beijing-Tianjin” Dual-Core Region Structure
The characteristics of dual-core region structure of Beijing-Tianjin and the development of their midpoint city – Langfang is analyzed and researched. It is proposed in this paper that theExpand
Abstract LB-50: TRIM3, the human homolog of Drosophila Brat, is a tumor suppressor that regulates asymmetric cell division (ACD) in glioblastoma stem cells
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Cancer stem cells, capable of self-renewal and multipotent differentiation, influence tumor behavior through a complex balanceExpand