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OBJECTIVES This study was designed to assess the functional significance of side branches after stent implantation in main vessels using fractional flow reserve (FFR). BACKGROUND Little is known about the functional significance of side branches after stent implantation in main vessels in coronary bifurcation lesions. METHODS Between May 2007 and(More)
OBJECTIVES This study sought to evaluate the ability of minimal luminal area (MLA) measured by intravascular ultrasound (IVUS) to assess the functional significance of coronary artery disease. BACKGROUND The use of IVUS to determine the functional significance of coronary artery lesions remains a matter for debate. METHODS From our prospective IVUS(More)
BACKGROUND The polygon of confluence (POC) represents the zone of confluence of the distal left main (LM), ostial left anterior descending (LAD), and ostial left circumflex (LCX) arteries. METHODS We used intravascular ultrasound (IVUS) to assess the POC pre and post-drug-eluting stent implantation for unprotected distal LM disease. Four segments within(More)
BACKGROUND Many ST-segment elevation myocardial infarction (STEMI) patients have multivessel disease. There is still controversy in treatment strategy in STEMI patients with multivessel disease. We compared clinical outcomes of multivessel revascularization with infarct- related artery (IRA) revascularization in STEMI patients. METHODS The 1,644 STEMI(More)
BACKGROUND The long-term prognosis of patients with variant angina presenting with aborted sudden cardiac death (ASCD) is unknown. OBJECTIVES The purpose of this study was to evaluate the long-term mortality and ventricular tachyarrhythmic events of variant angina with and without ASCD. METHODS Between March 1996 and September 2014, 188 patients with(More)
OBJECTIVE The value of multivessel revascularisation in cardiogenic shock and multivessel disease (MVD) is still not clear. We compared outcomes following culprit vessel or multivessel revascularisation in patients with ST-elevation myocardial infarction (STEMI), cardiogenic shock and MVD. METHODS From 16 620 patients with STEMI who underwent primary(More)
OBJECTIVES The aim of this study was to compare treatment effects of drug-eluting stents (DES) or coronary artery bypass grafting (CABG) for left main coronary artery (LMCA) disease according to the complexity of atherosclerotic disease burden. BACKGROUND Limited information is available on the relationships between the extent of coronary atherosclerosis(More)
PURPOSE Adipose-derived stem cells (ADSCs) are known to be potentially effective in regeneration of damaged tissue. We aimed to assess the effectiveness of intracoronary administration of ADSCs in reducing the infarction area and improving function after acute transmural myocardial infarction (MI) in a porcine model. MATERIALS AND METHODS ADSCs were(More)
BACKGROUND This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS A total of 1914 consecutive patients with multivessel coronary disease undergoing drug-eluting stent implantation(More)
Statins are primarily metabolized by cytochrome P450 3A4 (CYP3A4), which reduces clopidogrel to its active metabolite. Recent studies suggest that CYP3A4-metabolized statins attenuate clopidogrel’s anti-aggregatory effect on platelets. We aimed to assess the impact of concomitant CYP3A4-metabolized statin and clopidogrel use on antiplatelet activity and(More)