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Online social networks (OSNs) are popular collaboration and communication tools for millions of users and their friends. Unfortunately, in the wrong hands, they are also effective tools for executing spam campaigns and spreading malware. Intuitively, a user is more likely to respond to a message from a Facebook friend than from a stranger, thus making(More)
mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3' end cleavage of nascent mRNAs and addition of the poly(A) tail, which plays important roles in many aspects of the cellular metabolism of mRNA. The process is controlled by various cis-acting elements surrounding the cleavage site, and their binding factors. In this study, we(More)
Messenger RNA polyadenylation is one of the key post-transcriptional events in eukaryotic cells. A large number of genes in mammalian species can undergo alternative polyadenylation, which leads to mRNAs with variable 3' ends. As the 3' end of mRNAs often contains cis elements important for mRNA stability, mRNA localization and translation, the implications(More)
BACKGROUND Alignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure alignment. However, existing tools either require a large number of prealigned structures or suffer from high time complexities. This makes it difficult for the tools to process RNAs(More)
An increasing amount of research has recently focused on representing affective states as continuous numerical values on multiple dimensions , such as the valence-arousal (VA) space. Compared to the categorical approach that represents affective states as several classes (e.g., positive and negative), the dimensional approach can provide more fine-grained(More)
Test case generation is the most important part of the testing efforts, the automation of specification based test case generation needs formal or semi-formal specifications. As a semi-formal modelling language, UML is widely used to describe analysis and design specifications by both academia and industry, thus UML models become the sources of test(More)
Dopaminergic (DAergic) neuronal activity in the ventral tegmental area (VTA) is thought to contribute generally to pleasure, reward, and drug reinforcement and has been implicated in nicotine dependence. nAChRs expressed in the VTA exhibit diverse subunit compositions, but the functional and pharmacological properties are largely unknown. Here, using(More)
Amyloid-beta (Abeta) accumulation and aggregation are thought to contribute to the pathogenesis of Alzheimer's disease (AD). In AD, there is a selective decrease in the numbers of radioligand binding sites corresponding to the most abundant nicotinic acetylcholine receptor (nAChR) subtype, which contains human alpha4 and beta2 subunits (halpha4beta2-nAChR).(More)
UNLABELLED Accurately mapping RNA-Seq reads to the reference genome is a critical step for performing downstream analysis such as transcript assembly, isoform detection and quantification. Many tools have been developed; however, given the huge size of the next generation sequencing datasets and the complexity of the transcriptome, RNA-Seq read mapping(More)