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Online social networks (OSNs) are popular collaboration and communication tools for millions of users and their friends. Unfortunately, in the wrong hands, they are also effective tools for executing spam campaigns and spreading malware. Intuitively, a user is more likely to respond to a message from a Facebook friend than from a stranger, thus making(More)
mRNA polyadenylation is a critical cellular process in eukaryotes. It involves 3' end cleavage of nascent mRNAs and addition of the poly(A) tail, which plays important roles in many aspects of the cellular metabolism of mRNA. The process is controlled by various cis-acting elements surrounding the cleavage site, and their binding factors. In this study, we(More)
We present a novel method for aligning images in an HDR (high-dynamic-range) image stack to produce a new exposure stack where all the images are aligned and appear as if they were taken simultaneously, even in the case of highly dynamic scenes. Our method produces plausible results even where the image used as a reference is either too dark or bright to(More)
Polyadenylation is an essential step for the maturation of almost all cellular mRNAs in eukaryotes. In human cells, most poly(A) sites are flanked by the upstream AAUAAA hexamer or a close variant, and downstream U/GU-rich elements. In yeast and plants, additional cis elements have been found to be located upstream of the poly(A) site, including UGUA, UAUA,(More)
Representing a basal branch of arachnids, scorpions are known as 'living fossils' that maintain an ancient anatomy and are adapted to have survived extreme climate changes. Here we report the genome sequence of Mesobuthus martensii, containing 32,016 protein-coding genes, the most among sequenced arthropods. Although M. martensii appears to evolve(More)
Long non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer. Highly upregulated in liver cancer (HULC), an lncRNA, has recently been revealed to be involved in hepatocellular carcinoma development and progression. It remains unclear, however, whether HULC plays an oncogenic role in human gastric cancer (GC). In the present study, we(More)
An increasing amount of research has recently focused on representing affective states as continuous numerical values on multiple dimensions, such as the valence-arousal (VA) space. Compared to the categorical approach that represents affective states as several classes (e.g., positive and negative), the dimensional approach can provide more finegrained(More)
As a major component of plant cell wall, lignin plays important roles in mechanical support, water transport, and stress responses. As the main cause for the recalcitrance of plant cell wall, lignin modification has been a major task for bioenergy feedstock improvement. The study of the evolution and function of lignin biosynthesis genes thus has two-fold(More)
UNLABELLED Accurately mapping RNA-Seq reads to the reference genome is a critical step for performing downstream analysis such as transcript assembly, isoform detection and quantification. Many tools have been developed; however, given the huge size of the next generation sequencing datasets and the complexity of the transcriptome, RNA-Seq read mapping(More)
The CHI conference has grown rapidly over the last 26 years. We present a quantitative analysis on the countries and organizations that contribute to its success. Only 7.8 percent of the countries are responsible for 80 percent of the papers in the CHI proceedings, and the USA is clearly the country with most papers. But the success of a country or(More)