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BACKGROUND Current clinical therapy of non-small cell lung cancer depends on histo-pathological classification. This approach poorly predicts clinical outcome for individual patients. Gene expression profiling holds promise to improve clinical stratification, thus paving the way for individualized therapy. METHODOLOGY AND PRINCIPAL FINDINGS A genome-wide(More)
One of the complexes formed by the hematopoietic transcription factor Gata1 is a complex with the Ldb1 (LIM domain-binding protein 1) and Tal1 proteins. It is known to be important for the development and differentiation of the erythroid cell lineage and is thought to be implicated in long-range interactions. Here, the dynamics of the composition of the(More)
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults. Several contributory factors, both genetic and environmental, have been identified but others remain elusive. HPFH was found in 10 of 27 members from a Maltese family. We used a genome-wide SNP scan followed by linkage analysis(More)
The effects of sodium nitroprusside (SNP, a donor of NO) on cadmium (Cd) toxicity in ryegrass seedlings (Lolium perenne L.) were studied by investigating the symptoms, plant growth, chlorophyll content, lipid peroxidation, H+-ATPase enzyme and antioxidative enzymes. Addition of 100 μM CdCl2 caused serious chlorosis and inhibited the growth of ryegrass(More)
Zinc (Zn) is a necessary element for plants, but excess Zn can be detrimental. To investigate Zn toxicity, rapeseed (Brassica napus) seedlings were treated with 0.07-1.12 mM Zn for 7d. Inhibition of plant growth along with root damage, chlorosis and decreased chlorophyll (a and b) content in newly expanded leaves (the second and third leaves formed(More)
The HMG-box transcription factor Sox2 plays a role throughout neurogenesis and also acts at other stages of development, as illustrated by the multiple organs affected in the anophthalmia syndrome caused by SOX2 mutations. Here we combined proteomic and genomic approaches to characterize gene regulation by Sox2 in neural stem cells. Chd7, a chromatin(More)
Companding transform is a simple and efficient method in reducing the Peak-to-Average Power Ratio (PAPR) of Orthogonal Frequency Division Multiplexing (OFDM) systems. In this paper, a novel nonlinear companding scheme is proposed to reduce the PAPR and improve Bit Error Rate (BER) for OFDM systems. This proposed scheme mainly focuses on compressing the(More)
BACKGROUND Biphenotypic acute leukemia is a rare disorder that is difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There is still a lack of studies in biphenotypic acute leukemia in a Chinese population. We present here a comprehensive investigation of the clinical and biological characteristics, and outcome of biphenotypic(More)
To investigate the effects of zinc (Zn) on aquatic macrophyte, the submerged plant Hydrilla verticillata (L.f.) Royle was cultured in control solution or together with 0.05-30 mg L(-1) Zn(2+) for 7 d. The alterations in nutrient uptake and antioxidative response were assayed. Zn stress increased the uptake of Cu, Fe, Mn, Mg, and Zn while decreased that of(More)