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We present in this paper a method to estimate four significant biological parameters of colon tissue. The interaction of light with colon tissue is modeled by two layers parameterized by biological parameters, which describe optical properties of the colon. This model is reversed using an optimization framework based on genetic algorithms. From a(More)
This article presents the use of Non-negative Matrix Fac-torization, a blind source separation algorithm, for the decomposition of human skin absorption spectra in its main pigments: melanin and hemoglobin. The evaluated spectra come from a Hyper-Spectral Image, which is the result of the processing of a Multi-Spectral Image by a neural network-based(More)
This article presents a multispectral imaging system which, coupled with a neural network-based algorithm, reconstructs reflectance cubes. The reflectance spectra are obtained using artificial neural-netwok reconstruction which generates reflectance cubes from acquired multispectral images. Then, a blind source separation algorithm based on Non-negative(More)
The wound healing assay is widely used for the quantitative analysis of highly regulated cellular events. In this essay, a wound is voluntarily produced on a confluent cell monolayer, and then the rate of wound reduction (WR) is characterized by processing images of the same regions of interest (ROIs) recorded at different time intervals. In this method,(More)
Blind Source Separation methods (BSS) aim for the decomposition of a given signal in its main components or source signals. Those techniques have been widely used in the literature for the analysis of biomedical images, in order to extract the main components of an organ or tissue under study. The analysis of skin images for the extraction of melanin and(More)
This article presents the use of blind source separation methods for the decomposition of cardiovascular tissue multi-spectral images in its main morphological components. The evaluated images were acquired with two kinds of systems: one based in a confocal configuration and another based in interference filters. The implemented source separation algorithms(More)
BACKGROUND AND OBJECTIVES Cell imaging is a widely-employed technique to analyze multiple biological processes. Therefore, simple, accurate and quantitative tools are needed to understand cellular events. For this purpose, Bio-EdIP was developed as a user-friendly tool to quantify confluence levels using cell culture images. METHODS The proposed algorithm(More)
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