Julius O. Enoru

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Parkinson's disease (PD) is a neurodegenerative aging disorder in which postmortem PD brain exhibits neuroinflammation, as well as synucleinopathy-associated protein phosphatase 2A (PP2A) enzymatic activity loss. Based on our translational research, we began evaluating the PD-repurposing-potential of an anti-inflammatory, neuroprotective, and PP2A(More)
In vitro metabolism evaluations for compounds in early development are typically conducted using liver microsomes and suspension hepatocytes. While these systems have been serving the drug development community, they have their limitations, with examples of “metabolite surprises” where metabolites which were not predicted or observed in vitro or in vivo(More)
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