Julio García-Paredes

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BACKGROUND We assessed the prevalence of R702W, G908R, and L1007fs coding mutations in the NOD2/CARD15 gene and the genotype-phenotype relation in Spanish patients with Crohn disease. METHODS A cohort of 204 unrelated patients with Crohn disease and 140 healthy controls were studied. The phenotype was established before commencement of genotyping.(More)
The precise mechanism of action of thiopurine drugs remains unclear despite more than 40 years of use. Recent knowledge in the field of apoptosis and a better insight into, as well as a rapid increase in their use in several important areas of clinical medicine justify this appraisal. This is a review of the recent advances in the knowledge of their(More)
BACKGROUND Crohn's disease is a heterogeneous disease from both genetic and clinical points of view. AIMS To look for associations between distinct genetic polymorphisms and clinical subgroups of the disease. SUBJECTS A total of 210 patients and 343 healthy control subjects, all adult, unrelated, white, Spanish individuals. METHODS DNA was purified(More)
OBJECTIVE To evaluate the efficacy and toxicity of infliximab for the treatment of fistulizing Crohn's disease. METHODS Consecutive patients with fistulizing Crohn's disease receiving infliximab were prospectively enrolled. Partial response was defined as a reduction of 50% or more from base-line in the number of draining fistulae. Complete response was(More)
Ninety patients with endoscopically proven duodenal ulcers, enrolled in this prospective, single-blind study, were randomized to sucralfate, 1 g q.i.d., 0.5 hour before meals on an empty stomach or at bedtime, or ranitidine, 150 mg b.i.d., for 4-8 weeks (phase I). Patients who healed during the treatment period were invited to participate in a maintenance(More)
The association of ulcerative colitis withdistinct HLA-DRB1 alleles has not been easy toascertain. Recent studies show that among HLA-DR2alleles, DRB1*15 but not DRB1*16, is associated with thedisease. Similarly, in the HLA-DR1 group, only DRB1*0103is increased in ulcerative colitis patients. The aim ofour study was to identify critical DRB1 residues(More)
BACKGROUND Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin-10 (IL-10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL-10 contains single nucleotide polymorphisms and 2(More)
OBJECTIVE The aim of this study is to report our experience with infliximab and analyse prognostic factors for response in Crohn's disease (CD). MATERIAL AND METHODS Consecutive patients were prospectively enrolled in the study when referred for infliximab infusion. Data collected included indication for infusion, patient epidemiological characteristics,(More)
UNLABELLED The inflammatory bowel disease is accompanied by cutaneous manifestations in approximately 10% of the cases. Neutrophilic dermatoses are located on the dermis and/or epidermis and are characterised on histological examination by the presence of an infiltrate that consists largely of neutrophils. The prototype of neutrophilic dematoses is(More)