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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues afterExpand
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  • Open Access
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.
BACKGROUND & AIMS The biliary tree is the target of cholangiopathies that are chronic cholestatic liver diseases characterized by loss of proliferative response and enhanced apoptosis ofExpand
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Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.
BACKGROUND & AIMS Cholangiopathies are characterized by progressive dysregulation of the balance between proliferation and death of cholangiocytes. In the course of cholestasis, cholangiocytesExpand
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Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.
Chronic cholestatic liver diseases are characterized by impaired balance between proliferation and death of cholangiocytes, as well as vanishing of bile ducts and liver failure. Ursodeoxycholic acidExpand
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Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis.
BACKGROUND & AIMS There is poor knowledge on the factors that modulate the growth of cholangiocytes, the epithelial cell target of cholangiopathies, which are diseases leading to progressive loss ofExpand
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Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
Background: Cholangiopathies impair the balance between proliferation and apoptosis of cholangiocytes leading to the disappearance of bile ducts and liver failure. Taurocholic acid (TC) is essentialExpand
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