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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans.
- A. Omenetti, A. Porrello, +12 authors A. Diehl
- The Journal of clinical investigation
- 1 October 2008
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after… Expand
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.
BACKGROUND & AIMS The biliary tree is the target of cholangiopathies that are chronic cholestatic liver diseases characterized by loss of proliferative response and enhanced apoptosis of… Expand
Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.
BACKGROUND & AIMS Cholangiopathies are characterized by progressive dysregulation of the balance between proliferation and death of cholangiocytes. In the course of cholestasis, cholangiocytes… Expand
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.
- M. Marzioni, H. Francis, +8 authors S. Glaser
- Medicine, Biology
- The American journal of pathology
- 1 February 2006
Chronic cholestatic liver diseases are characterized by impaired balance between proliferation and death of cholangiocytes, as well as vanishing of bile ducts and liver failure. Ursodeoxycholic acid… Expand
Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis.
BACKGROUND & AIMS There is poor knowledge on the factors that modulate the growth of cholangiocytes, the epithelial cell target of cholangiopathies, which are diseases leading to progressive loss of… Expand
Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
- M. Marzioni, Y. Ueno, +6 authors G. Alpini
- Liver international : official journal of the…
- 1 May 2007
Background: Cholangiopathies impair the balance between proliferation and apoptosis of cholangiocytes leading to the disappearance of bile ducts and liver failure. Taurocholic acid (TC) is essential… Expand
KNOCKOUT OF THE GENE FOR SECRETIN INHIBITS BILIARY HYPERPLASIA OF LARGE CHOLANGIOCYTES IN CHOLESTATIC MICE BY AN AUTOCRINE MECHANISM
Increased expression of serotonin N-acetyltransferase (AANAT, the key enzyme responsible for the synthesis of melatonin) in cholangiocytes causes inhibition of biliary proliferation: evidence for a…
LACK OF alpha-CALCITONIN GENE-RELATED PEPTIDE (alpha-CGRP) REDUCES BILE ACID-INDUCED INCREASE IN BILIARY PROLIFERATION