Juliet P. Hale

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The innervation pattern of inhibitory motor neurones of the locust has been revealed by intracellular recording from their cell bodies in the meso- and metathoracic ganglion and simultaneous recording from muscle fibres in a middle, or in a hind leg. Three neurones in each ganglion, the common inhibitor (CI = CI1), the anterior inhibitor (AI = CI2), and the(More)
PURPOSE Dactinomycin (actinomycin D) is an antitumor antibiotic used routinely to treat certain pediatric and adult cancers. Despite concerns over the incidence of toxicity, little is known about the pharmacology of dactinomycin. A study was done to investigate dactinomycin pharmacokinetics in children. EXPERIMENTAL DESIGN Dactinomycin was administered to(More)
Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutations and 32% were paternal uniparental disomy (pUPD). We(More)
BACKGROUND We recently demonstrated that administration of probiotics resulted in significant clinical improvement in very young children with moderate-to-severe atopic dermatitis (AD). The purpose of this study was to determine the underlying immunological effects that are associated with these apparent clinical benefits. METHODS Peripheral blood(More)
PURPOSE The purpose of this article is to describe the features, treatment, and risk factors for relapse of children with mature teratoma (MT) and immature teratoma (IT) to assist future treatment plans. PATIENTS AND METHODS Patients were younger than 16 years of age and referred to the UK Children's Cancer Study Group centers with biopsy-proven(More)
BACKGROUND We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma. METHODS EURAMOS-1 was an open-label, international, phase 3 randomised, controlled(More)
F atherhood is an important issue to young men surviving cancer as fertility may be impaired by treatment. A number of strategies to preserve fertility are available to adolescent males. Wide variation in practice for adolescent male fertility preservation has previously been shown in North America. No defining data for the UK are available. In the UK,(More)
The formation of platinum (Pt)-DNA adducts is thought to be crucial to the antitumor activity of cisplatin, and relationships between adduct formation in peripheral blood leukocytes (PBLs) and response to cisplatin therapy have been reported. The current study directly tests, for the first time, whether pharmacokinetic or other factors predominantly(More)
Pre-clinical studies indicate that cisplatin encapsulated in STEALTH®liposomes (SPI-77) retains anti-tumour activity, but has a much reduced toxicity, compared to native cisplatin. A phase I study was conducted to determine the toxicity and pharmacokinetics of SPI-77 administered to children with advanced cancer not amenable to other treatment. Paediatric(More)
The morphologies of three common inhibitory motor neurones which innervate muscles of a hind leg and the homologous three neurones which innervate muscles in a middle leg are described in relation to known commissures, tracts, and areas of neuropile in their ganglia. The neurones were stained individually by the intracellular injection of cobalt, and the(More)