Julien Volle

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Rat with excitotoxic neonatal ventral hippocampal lesions (NVHL rats) is considered as a heuristic neurodevelopmental model for studying schizophrenia. Extensive study of this model is limited by the lack of clear validity criteria of such lesions and because ascertaining of the lesions is realized postmortem with histological examination after completing(More)
BACKGROUND STOP/MAP6 null (KO) mice recapitulate behavioral abnormalities related to positive and negative symptoms and cognitive deficits of schizophrenia. Here, we investigated whether decreased expression of STOP/MAP6 proteins in heterozygous mice (only one allele expressed) would result in abnormal behavior related to those displayed by STOP null mice.(More)
Recently, evidence has been accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins and especially microtubule associated protein. Previous experiments have demonstrated that STOP gene deletion in mice leads to a phenotype mimicking some aspects of positive symptoms classically observed in schizophrenic patients.(More)
Anatomical and electrophysiological studies collectively suggest that the entorhinal cortex consists of several subregions, each of which is involved in the processing of different types of information. Consistent with this idea, we previously reported that the dorsolateral portion of the entorhinal cortex (DLE), but not the caudomedial portion, is(More)
1Université de Lyon, Lyon, F-69003, France; Université Lyon 1, Lyon, EA 4615; 2Centre Hospitalier le Vinatier, F-69677 Bron Cedex, France; 3Institut National de la Santé et de la Recherche Médicale Unité 836, Institut des Neurosciences de Grenoble, Université Joseph Fourier, 38042 Grenoble Cedex 9, France; 4Groupe Physiopathologie du Cytosquelette, Institut(More)
The ability to link events that are separated in time is important for extracting meaning from experiences and guiding behavior in the future. This ability likely requires the brain to continue representing events even after they have passed, a process that may involve the prefrontal cortex and takes the form of sustained, event-specific neuron activity.(More)
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