Julien Penichon

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Plasmacytoid dendritic cells (pDC) expressing FcγRIIa are antigen-presenting cells able to link innate and adaptive immunity and producing various cytokines and chemokines. Although highly restricted, they are able to replicate HIV-1. We determined the activity of anti-HIV-1 neutralizing antibodies (NAb) and non-neutralizing inhibitory antibodies (NNIAb) on(More)
On the basis of phylogenetic analyses, we uncovered a variant of the CDX2 homeobox gene, a major regulator of the development and homeostasis of the gut epithelium, also involved in cancer. This variant, miniCDX2, is generated by alternative splicing coupled to alternative translation initiation, and contains the DNA-binding homeodomain but is devoid of(More)
Background Plasmacytoid dendritic cells (PDCs) have been described to link innate and adaptive immunity. Indeed, these cells are able to capture and present antigens, and produce high amounts of cytokines, especially antiviral type I interferons. PDCs are productively infected by HIV in vitro and in vivo, and several studies have shown a decrease in(More)
Background Natural killer (NK) cells play an important role in antiviral immune responses; they kill HIV-1-infected cells either by direct lysis or through an antibody-dependent cellular cytotoxicity (ADCC) mechanism. HIV-1-specific ADCC were mainly detected using the CEM-NK target cell line. The aim of our study was to analyze the ADCC activity of various(More)
Mucosal tissues are the predominant sites for genital HIV-1 transmission. We investigated the mechanisms by which broadly neutralizing antibodies (bNAbs) inhibit HIV-1 replication in a coculture model including primary mucosal dendritic cells (DCs), such as Langerhans cells, interstitial dendritic cells, and CD4(+) T lymphocytes. We show that bNAbs(More)
Background Langerhans (LC) and interstitial dendritic cells (IDC) present in mucosal tissues are among the first HIV-1 target cells. Infected DC have been shown to transfer the virus to nearby CD4 T lymphocytes. We have demonstrated that neutralizing antibodies (NAb) were able to inhibit the transfer of HIV-1 from monocyte-derived DC to CD4-T lymphocytes.(More)
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