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UNLABELLED Flavivirus RNA synthesis is mediated by a multiprotein complex associated with the endoplasmic reticulum membrane, named the replication complex (RC). Within the flavivirus RC, NS4B, an… Continue Reading
Obesity and type 2 diabetes are chronic metabolic diseases, and those affected could benefit from the use of α-amylase inhibitors to manage starch intake. The pseudocyclics, wrightides Wr-AI1 to… Continue Reading
The transmembrane NS4B protein of dengue virus (DENV) is a validated antiviral target that plays important roles in viral replication and invasion of innate immune response. The first 125 amino acids… Continue Reading
Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico… Continue Reading
Flavivirus non-structural protein 5 (NS5) contains a N-terminal methyltransferase domain (MTase) and a C-terminal polymerase domain (RdRp) fused through a nine-amino acid linker. While the individual… Continue Reading