Julien Bryois

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DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and(More)
DNA methylation is an essential epigenetic mark whose role in gene regulation and its dependency on genomic sequence and environment are not fully understood. In this study we provide novel insights into the mechanistic relationships between genetic variation, DNA methylation and transcriptome sequencing data in three different cell-types of the GenCord(More)
Drosophila melanogaster has one of the best characterized metazoan genomes in terms of functionally annotated regulatory elements. To explore how these elements contribute to gene regulation, we need convenient tools to identify the proteins that bind to them. Here we describe the development and validation of a high-throughput yeast one-hybrid platform,(More)
Gene expression is a heritable cellular phenotype that defines the function of a cell and can lead to diseases in case of misregulation. In order to detect genetic variations affecting gene expression, we performed association analysis of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) with gene expression measured in 869(More)
Understanding how genetic variation affects distinct cellular phenotypes, such as gene expression levels, alternative splicing and DNA methylation levels, is essential for better understanding of complex diseases and traits. Furthermore, how inter-individual variation of DNA methylation is associated to gene expression is just starting to be studied. In(More)
PURPOSE Mutations at some retinitis pigmentosa (RP) loci are associated with variable penetrance and expressivity, exacerbating diagnostic challenges. The purpose of this study was to dissect the genetic underpinnings of nonsyndromic RP with variable age of onset in a large Mexican family. METHODS We ascertained members of a large, multigenerational(More)
Evaluation of Chromatin Accessibility in Prefrontal Cortex of Schizophrenia Cases and Controls Julien Bryois *, Melanie E Garrett *, Lingyun Song *, Alexias Safi , Paola Giusti-Rodriguez , Graham D Johnson , Alfonso Buil Demur , John F Fullard , Panos Roussos , Pamela Sklar , Schahram Akbarian , Vahram Haroutunian , Craig A Stockmeier , Gregory A Wray ,(More)
Author Affiliations: 9 1 MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, 10 Psychology & Neuroscience, King’s College London, London SE5 8AF, UK. 11 2 NIHR Biomedical Research Centre for Mental Health, South London and Maudsley 12 NHS Trust, London SE5 8AF, UK. 13 3 Department of Medical Epidemiology and Biostatistics,(More)
Gene expression is dependent on genetic and environmental factors. In the last decade, a large body of research has significantly improved our understanding of the genetic architecture of gene expression. However, it remains unclear whether genetic effects on gene expression remain stable over time. Here, we show, using longitudinal whole-blood gene(More)
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