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Nanocarriers for the targeted treatment of ovarian cancers.
Ovarian cancer is the leading cause of death from gynecological malignancies worldwide. Although the majority of tumors initially respond to standard treatments combining surgery and chemotherapyExpand
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Rapid and soft formulation of folate-functionalized nanoparticles for the targeted delivery of tripentone in ovarian carcinoma.
We report the development of folate-functionalized nanoparticles able to target folate receptors, and to deliver a poorly water soluble cytotoxic agent, a tripentone, in ovarian carcinoma. TheExpand
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Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family
BackgroundOur work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours,Expand
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Origine moléculaire de l’allergie au lait de vache
Introduction Aucun modele unifie n’explique au niveau moleculaire pourquoi une proteine banale pour certains acquiert pour d’autres la capacite d’induire une allergie. Nous avons observe et decrit unExpand
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Vectorisation nanoparticulaire d'agents cytotoxiques originaux en vue du traitement ciblé des tumeurs ovariennes
L’objectif de ce travail de these etait de developper des nanoparticules capables de delivrer specifiquement une tripentone (compose mr22388 developpe par le CERMN) dans les cellules tumoralesExpand
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Clinical utility of in depth RNA sequencing for non-metastatic triple negative breast cancers.
1088 Background: Triple negative breast cancers (TNBC), that represent the most severe form of the disease, are not amenable to current targeted therapies. RNA DNA divergences (RDD) reflect changesExpand
Abstract 5287: RNA DNA divergences: An unsuspected marker of cancer genomic instability accurately predicts triple-negative breast cancer severity
Next generation sequencing provides 3 measures of cancer genomic instability i.e. somatic DNA variations, differential gene expression and RNA DNA divergences (RDD). The latter reflects changes inExpand
Infidélité de la transcription et origine de l’allergie
Introduction Les donnees de sequencage de nouvelle generation mettent en evidence l’existence de lectures alternatives de la sequence d’ADN. Cette infidelite de transcription (IT) introduit desExpand