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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen, progesterone, and HER2 receptors. Because of the absence of identified targets and targeted therapies, and dueExpand
Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging
Surface-enhanced resonance Raman scattering gold nanostars allow detection of macro- and microscopic foci of premalignant and cancerous lesions in vivo. Seeing Nanostars Microscopic tumors may beExpand
Tolerance and efficacy of emamectin benzoate and ivermectin for the treatment of Pseudocapillaria tomentosa in laboratory zebrafish (Danio rerio).
Tolerance of adult zebrafish and efficacy of emamectin benzoate and ivermectin in eliminating Pseudocapillaria tomentosa infection were evaluated. In the tolerance study, behavioral changes,Expand
Pathology of Aging in NOD scid gamma Female Mice
In the past decade, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneousExpand
Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis
PTPRD encodes the protein tyrosine phosphatase receptor type D and is frequently inactivated across many human cancers. Despite its frequent inactivation, it is unknown whether loss of PTPRD promotesExpand
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer’s disease (AD). Here we use cellular and animalExpand
Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling
  • Disharee Nath, Xiang Li, +16 authors L. Kotula
  • Biology, Medicine
  • Cell Communication and Signaling
  • 18 September 2019
Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease.Expand
Trichodina xenopodus, a ciliated protozoan, in a laboratory-maintained Xenopus laevis.
A postmortem evaluation of a domestically bred, adult, female Xenopus laevis revealed the presence of a urinary bladder protozoan consistent with Trichodina xenopodus. T. xenopodus is considered anExpand
Strategies to prevent, treat, and provoke Corynebacterium-associated hyperkeratosis in athymic nude mice.
Athymic nude mice infected with Corynebacterium bovis typically exhibit transient hyperkeratotic dermatitis. Our vivarium experienced an increased incidence of disease characterized by persistentExpand
Anatomic, hematologic, and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone.
Metabolic syndrome is a condition that typically includes central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension. Disruption of the hypothalamic-pituitary-adrenalExpand