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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta.
Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell proliferation. Here, we demonstrate that PD-1Expand
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The contemporary librarian: Skills, knowledge and attributes required in a world of emerging technologies
Librarian 2.0 was broadly viewed by participants as being about change whilst librarian 2 was perceived as not a new creation but just about good librarian practices. Expand
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PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
Engagement of the immunoinhibitory receptor, programmed death‐1 (PD‐1) attenuates T‐cell receptor (TCR)‐mediated activation of IL‐2 production and T‐cell proliferation. Here, we demonstrate that PD‐1Expand
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Cultural institutions and Web 2.0
The document reports upon an exploratory survey of the approaches that Australian cultural institutions are implementing to meet Web 2.0 challenges. It is given context by a review that is made ofExpand
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Iminoheterocycles as gamma-secretase modulators.
The synthesis of a novel series of iminoheterocycles and their structure-activity relationship (SAR) as modulators of gamma-secretase activity will be detailed. Encouraging SAR generated from aExpand
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Redox control of iron regulatory protein 2 stability
Iron regulatory protein 2 (IRP2) is a critical switch for cellular and systemic iron homeostasis. In iron‐deficient or hypoxic cells, IRP2 binds to mRNAs containing iron responsive elements (IREs)Expand
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Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
BackgroundHyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation isExpand
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Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
The protein kinase C (PKC) family of serine/threonine kinases is implicated in a wide variety of cellular processes. The PKC theta (PKCtheta) isoform is involved in TCR signal transduction and T cellExpand
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Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence.
The human beta-secretase enzyme, BACE1, mediates a critical step in the production of A beta(40) and A beta(42) peptides which are responsible for the severe neuronal cell death and insoluble amyloidExpand
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Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
Gamma-secretase catalyzes the proteolytic processing of a number of integral membrane proteins, including amyloid precursor protein (APP) and Notch. The native gamma-secretase is a heterogeneousExpand
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