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BACKGROUND Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer. Because survival is often favorable regardless of therapy, treatment decisions may depend on other therapy-specific health outcomes. In this study, we compared the effects of two treatments on urinary,(More)
This study examines mammography-enhancing intervention studies that focus on women in groups with historically lower rates of mammography use than the general population. These groups consist of women who are disproportionately older, poorer, of racial-ethnic minorities, have lower levels of formal education, and live in rural areas. We refer to them as(More)
BACKGROUND Overdiagnosis of clinically insignificant prostate cancer is considered a major potential drawback of prostate-specific antigen (PSA) screening. Quantitative estimates of the magnitude of this problem are, however, lacking. We estimated rates of prostate cancer overdiagnosis due to PSA testing that are consistent with the observed incidence of(More)
We compare two approaches to the identification of individual significant outcomes when a comparison of two groups involves multiple outcome variables. The approaches are all designed to control the familywise error rate (FWE) with any subset of the null hypothesis being true (in the strong sense). The first approach is initially to use a global test of the(More)
Prostate cancer is the most commonly diagnosed (non-skin) cancer among men in the United States, with 179 000 new cases and 37 000 deaths expected in 1999 (1). Although $5 billion is spent annually for the care of those diagnosed with prostate cancer (2), a systematic evaluation of practice patterns and the impact of treatments on health-related quality of(More)
Over the past 10 years, breast cancer screening has increased greatly among women in the United States. Among women ages 50 and older, more than 56% reported having received a clinical breast exam and mam-mogram (X-ray images of the breast) in the 2mography rates doubled or tripled for most ethnic groups over that period. In the past decade, the progress(More)
Diploid and diploid-triploid mosaic individuals of Platemys platycephala were found in natural populations. In mosaic specimens, the blood, spleen, liver, and testis contained both diploid and triploid cells. The ratio of triploid to diploid cells was more variable among individuals than among somatic tissues within an individual. Only diploid cells(More)
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